First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
National Clinical Research Center for Chinese Acupuncture and Moxibustion, Tianjin 300193.
Zhen Ci Yan Jiu. 2024 Jan 25;49(1):71-78. doi: 10.13702/j.1000-0607.20220909.
Acupuncture has a positive effect in the treatment of ischemic stroke (IS). A number of studies have confirmed that the role of acupuncture in the treatment of IS, which is closely related to its functions of regulating mitochondrial functions. In the present article, we review the mechanisms of acupuncture underlying improvement of mitochondria in the treatment of IS from 4 aspects： 1) protecting mitochondrial structure integrity, 2) regulative effect on mitochondrial functional activities, including regulating energy metabolism, reducing oxidative stress, suppressing calcium overload, and regulating mitochondrial membrane potential changes, 3) regulating mitochondrial quality control system, including promoting mitochondrial biosynthesis, regulating mitochondrial dynamics and apoptosis, and 4) regula-ting mitochondria-related apoptosis pathways. All of these may provide a theoretical basis for acupuncture in the treatment of IS and a reference for further research.
针灸在缺血性脑卒中（IS）的治疗中具有积极作用。许多研究已经证实，针灸在 IS 治疗中的作用与其调节线粒体功能密切相关。本文从 4 个方面综述了针灸改善 IS 中线粒体的作用机制：1）保护线粒体结构完整性；2）调节线粒体功能活动，包括调节能量代谢、减轻氧化应激、抑制钙超载和调节线粒体膜电位变化；3）调节线粒体质量控制系统，包括促进线粒体生物合成、调节线粒体动力学和细胞凋亡；4）调节与线粒体相关的凋亡途径。这些可能为针灸治疗 IS 提供理论依据，并为进一步研究提供参考。
