Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
PeerJ. 2024 Jan 15;12:e16825. doi: 10.7717/peerj.16825. eCollection 2024.
Macrophages and T cells in the tumor microenvironment (TME) play an important role in tumorigenesis and progression. However, TME is also characterized by metabolic reprogramming, which may affect macrophage and metabolic activity of T cells and promote tumor escape. Immunotherapy is an approach to fight tumors by stimulating the immune system in the host, but requires support and modulation of cellular metabolism. In this process, the metabolic roles of macrophages and T cells become increasingly important, and their metabolic status and interactions play a critical role in the success of immunotherapy. Therefore, understanding the metabolic state of T cells and macrophages in the TME and the impact of metabolic reprogramming on tumor therapy will help optimize subsequent immunotherapy strategies.
肿瘤微环境（TME）中的巨噬细胞和 T 细胞在肿瘤发生和进展中发挥着重要作用。然而，TME 还具有代谢重编程的特点，这可能会影响巨噬细胞和 T 细胞的代谢活性，并促进肿瘤逃逸。免疫疗法是一种通过刺激宿主免疫系统来对抗肿瘤的方法，但需要细胞代谢的支持和调节。在这个过程中，巨噬细胞和 T 细胞的代谢作用变得越来越重要，它们的代谢状态和相互作用对免疫疗法的成功起着关键作用。因此，了解 TME 中 T 细胞和巨噬细胞的代谢状态以及代谢重编程对肿瘤治疗的影响，将有助于优化后续的免疫疗法策略。
