Srivastava Vikas, Singh Shalendra
Brig AFMS (P&T), O/o DGAFMS, New Delhi, India.
Senior Advisor (Anaesthesia) & Neuroanaesthesiologist, Command Hospital (Northern Commmand), Udhampur, India.
Med J Armed Forces India. 2024 Jan-Feb;80(1):4-9. doi: 10.1016/j.mjafi.2023.10.010. Epub 2023 Dec 26.
Despite significant advancements in medical research, sepsis persists as a leading cause of mortality in intensive care units (ICUs). Sepsis intricately contributes to organ failure, amplifying both morbidity and mortality. In these instances, a comprehensive comprehension of the physiology of each organ is imperative for accurate diagnosis and effective management. Within the context of an ICU clinical scenario, a meticulous evaluation and monitoring of six pivotal organ systems cardiovascular, renal, respiratory, neurological, hematological, and hepatic are essential. The primary objective in managing sepsis-induced organ failure is the early detection and intervention, encompassing timely administration of antibiotics, identification and control of the infection source, and implementation of supportive therapy. Despite the extensive body of medical literature, there is a conspicuous absence of evidence-based multi-organ management strategies for such patients. The intricate interplay between organs, commonly referred to as organ crosstalk, presents a formidable challenge in navigating the complexities of sepsis management.
尽管医学研究取得了重大进展，但脓毒症仍然是重症监护病房（ICU）死亡的主要原因。脓毒症复杂地导致器官衰竭，增加发病率和死亡率。在这些情况下，全面了解每个器官的生理学对于准确诊断和有效管理至关重要。在ICU临床场景中，对六个关键器官系统——心血管、肾脏、呼吸、神经、血液和肝脏进行细致评估和监测至关重要。管理脓毒症诱导的器官衰竭的主要目标是早期检测和干预，包括及时使用抗生素、识别和控制感染源以及实施支持治疗。尽管有大量医学文献，但明显缺乏针对此类患者的循证多器官管理策略。器官之间复杂的相互作用，通常称为器官串扰，在应对脓毒症管理的复杂性方面构成了巨大挑战。
