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在一个地理位置和遗传上相对孤立的社会中,髌脱位和滑车发育不良的高发率:来自法罗群岛膝关节队列的观察性全国队列研究。

High prevalence of patellar dislocation and trochlear dysplasia in a geographically and genetically isolated society: an observational national cohort study from the Faroese Knee Cohort.

机构信息

Department of Orthopedic Surgery, National Hospital of the Faroe Islands, Torshavn, the Faroe Islands.

Interdisciplinary Orthopedics, Aalborg University Hospital.

出版信息

Acta Orthop. 2024 Jan 18;95:14-19. doi: 10.2340/17453674.2024.35229.

DOI:10.2340/17453674.2024.35229
PMID:38240376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10798052/
Abstract

BACKGROUND AND PURPOSE

We aimed to calculate the prevalence of patellar dislocation (PD) and trochlear dysplasia (TD) in a national cohort aged 15-19 years in the Faroe Island.

PATIENTS AND METHODS

All inhabitants in the Faroe Islands aged 15-19 years were invited to answer an online survey, including demographics and questions regarding prior PD. Participants with prior PD were invited for radiographs and MRI of both knees to be taken. Trochlear dysplasia was defined as one of the following: Dejour type A-D on radiographs, lateral trochlear inclination angle (LTI) < 11°, or trochlear depth < 3 mm on MRI.

RESULTS

3,749 individuals were contacted, 41 were excluded, and 1,638 (44%) completed the survey. 146 reported a prior PD (the PD cohort) and 100 accepted to participate and have radiographs and MRI taken of both knees (the clinical PD cohort), 76 of whom were diagnosed with TD. The national prevalence of PD was 8.9%. The national prevalence of symptomatic TD was 6.8%. The prevalence of TD in the clinical PD cohort was 76%. TD was bilateral in 78% of TD patients, but only 27% of patients with bilateral TD had PD in both knees.

CONCLUSION

The prevalence of PD in the Faroe Islands is found to be very high. The national prevalence of TD and the prevalence of TD in participants with prior PD is high, indicating a potential genetic influence.

摘要

背景与目的

我们旨在计算法罗群岛 15-19 岁年龄段人群中髌骨脱位(PD)和滑车发育不良(TD)的患病率。

患者与方法

法罗群岛所有 15-19 岁的居民都被邀请回答在线调查,内容包括人口统计学资料和先前 PD 的问题。有 PD 病史的参与者被邀请进行双膝的 X 线和 MRI 检查。滑车发育不良的定义为以下之一:X 线上的 Dejour 分型 A-D,外侧滑车倾斜角(LTI)<11°,或 MRI 上的滑车深度<3mm。

结果

共联系了 3749 人,排除了 41 人,有 1638 人(44%)完成了调查。146 人报告了先前 PD(PD 队列),100 人同意参加并对双膝进行 X 线和 MRI 检查(临床 PD 队列),其中 76 人被诊断为 TD。PD 的全国患病率为 8.9%。有症状 TD 的全国患病率为 6.8%。临床 PD 队列中 TD 的患病率为 76%。78%的 TD 患者为双侧,而只有 27%的双侧 TD 患者双膝均有 PD。

结论

法罗群岛的 PD 患病率非常高。TD 的全国患病率和有 PD 病史患者的 TD 患病率均较高,表明可能存在遗传影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/0c42578ac90c/ActaO-95-35229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/ef282e3a6827/ActaO-95-35229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/7d37528f45d2/ActaO-95-35229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/0c42578ac90c/ActaO-95-35229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/ef282e3a6827/ActaO-95-35229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/7d37528f45d2/ActaO-95-35229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/10798052/0c42578ac90c/ActaO-95-35229-g003.jpg

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本文引用的文献

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Knee Surg Sports Traumatol Arthrosc. 2023 Sep;31(9):3701-3733. doi: 10.1007/s00167-022-07265-z. Epub 2023 Jan 11.
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Epidemiology of patellar dislocations in the United States from 2001 to 2020: results of a national emergency department database.2001 年至 2020 年美国髌脱位的流行病学:国家急诊数据库研究结果。
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FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands.
法罗群岛人群中的编码变异分布解析。
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The Evaluation of Trochlear Osseous Morphology: An Epidemiologic Study.滑车骨形态学评估:一项流行病学研究。
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