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Helios 鉴定出具有增强功能表型的循环滤泡辅助 T 细胞，并且在系统性红斑狼疮患者中增加。

Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus.

机构信息

Department of Clinical Laboratory, Peking University People's Hospital, 11# Xizhimen South Street, Beijing, 100044, China.

School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

出版信息

Clin Exp Med. 2024 Jan 19;24(1):5. doi: 10.1007/s10238-023-01289-6.

DOI:10.1007/s10238-023-01289-6
PMID:38240853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10799143/
Abstract

Helios was related to the immunosuppressive capacity and stability of regulatory T cells. However, the significance of Helios in follicular help T (TFH) and follicular regulatory T (TFR) cells is unclear. This research aimed to clarify the significance of Helios (IKZF2) in TFH and TFR cells and its clinical value in systemic lupus erythematosus (SLE). IKZF2 mRNA in different cell subsets was analyzed. Helios+ percentages in TFH and TFR cells were identified in the peripheral blood of 75 SLE patients and 62 HCs (healthy controls). PD-1 and ICOS expression were compared between Helios+ and Helios- cells. The capacity of TFH cells to secrete IL-21 and TFR cells to secrete IL-10 was measured. Correlation analysis and receiver operating characteristic (ROC) curve analysis were conducted to assess the clinical significance of Helios-related TFH and TFR cell subsets in SLE. There was Helios expression in TFH and TFR cells. PD-1 and ICOS were lower in Helios+ TFR than in Helios- TFR. ICOS was increased in Helios+ TFH cells compared with Helios- TFH cells, and ICOS in Helios+ TFH cells was downregulated in SLE. Helios+ TFH cells secreted more IL-21 than Helios- TFH cells, and Helios+ TFH cells from SLE patients had a stronger IL-21 secretion than HCs. Helios+ TFH percentages were negatively correlated with C3 and C4 and positively related to CRP and SLEDAI, and the AUC of Helios+ TFH to distinguish SLE from HC was 0.7959. Helios characterizes circulating TFH cells with enhanced function. Increased Helios+ TFH cells could reflect the autoimmune status of SLE.

摘要

Helios 与调节性 T 细胞的免疫抑制能力和稳定性有关。然而，Helios 在滤泡辅助 T（TFH）和滤泡调节性 T（TFR）细胞中的意义尚不清楚。本研究旨在阐明 Helios（IKZF2）在 TFH 和 TFR 细胞中的意义及其在系统性红斑狼疮（SLE）中的临床价值。分析了不同细胞亚群中的 IKZF2mRNA。在 75 例 SLE 患者和 62 例健康对照者（HC）的外周血中鉴定 TFH 和 TFR 细胞中的 Helios+百分比。比较 Helios+和 Helios-细胞中 PD-1 和 ICOS 的表达。测量 TFH 细胞分泌 IL-21 和 TFR 细胞分泌 IL-10 的能力。进行相关性分析和受试者工作特征（ROC）曲线分析，以评估 Helios 相关 TFH 和 TFR 细胞亚群在 SLE 中的临床意义。TFH 和 TFR 细胞中有 Helios 表达。Helios-TFR 中的 PD-1 和 ICOS 低于 Helios-TFR。与 Helios-TFH 细胞相比，Helios+TFH 细胞中的 ICOS 增加，且 SLE 患者的 Helios+TFH 细胞中的 ICOS 下调。Helios+TFH 细胞分泌的 IL-21 多于 Helios-TFH 细胞，且来自 SLE 患者的 Helios+TFH 细胞的 IL-21 分泌更强。Helios+TFH 百分比与 C3 和 C4 呈负相关，与 CRP 和 SLEDAI 呈正相关，Helios+TFH 区分 SLE 与 HC 的 AUC 为 0.7959。Helios 特征是具有增强功能的循环 TFH 细胞。增加的 Helios+TFH 细胞可以反映 SLE 的自身免疫状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/5d2f93a5d3f1/10238_2023_1289_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/f290dd6a3687/10238_2023_1289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/26535d195e33/10238_2023_1289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/70e0980ab225/10238_2023_1289_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/f96c5c8394bf/10238_2023_1289_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/7f9fe21bc5f1/10238_2023_1289_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/5d2f93a5d3f1/10238_2023_1289_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/f290dd6a3687/10238_2023_1289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/26535d195e33/10238_2023_1289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/70e0980ab225/10238_2023_1289_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/f96c5c8394bf/10238_2023_1289_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/7f9fe21bc5f1/10238_2023_1289_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0795/10799143/5d2f93a5d3f1/10238_2023_1289_Fig6_HTML.jpg

相似文献

[1]
Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus.

Clin Exp Med. 2024-1-19

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Potential Biomarkers in Systemic Lupus Erythematosus.

JMA J. 2025-7-15

本文引用的文献

[1]
A T follicular helper cell origin for T regulatory type 1 cells.

Cell Mol Immunol. 2023-5

[2]
Peripheral Immunophenotype in IgG4-Related Disease and Its Association with Clinical Phenotypes and Disease Activity.

Cells. 2023-2-20

[3]
IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patient.

Clin Immunol. 2022-11

[4]
Changes in the expression of T-cell factor-1 in follicular helper T cells reflect the condition of systemic lupus erythematosus patients.

Int Immunopharmacol. 2022-7

[5]
A Novel Long Noncoding RNA lincRNA00892 Activates CD4 T Cells in Systemic Lupus Erythematosus by Regulating CD40L.

Front Pharmacol. 2021-10-11

[6]
Helios is a marker, not a driver, of human Treg stability.

Eur J Immunol. 2022-1

[7]
BCL6 controls contact-dependent help delivery during follicular T-B cell interactions.

Immunity. 2021-10-12

[8]
Acute pharmacological degradation of Helios destabilizes regulatory T cells.

Nat Chem Biol. 2021-6

[9]
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells.

Commun Biol. 2021-5-12

[10]
Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients.

Eur J Immunol. 2021-7

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