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患者特发性脊柱侧凸特定运动疗法的影响:系统评价和随机对照试验的荟萃分析,采用观察性研究进行亚组分析。

The impact of patient scoliosis-specific exercises for adolescent idiopathic scoliosis: a systematic review and meta-analysis of randomized controlled trials with subgroup analysis using observational studies.

机构信息

Department of Rehabilitation Services, University Hospitals, Cleveland, OH, USA.

College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.

出版信息

Spine Deform. 2024 May;12(3):545-559. doi: 10.1007/s43390-023-00810-x. Epub 2024 Jan 20.

Abstract

PURPOSE

Adolescent idiopathic scoliosis (AIS) is a common pediatric spinal deformity frequently treated with patient scoliosis-specific exercises (PSSE). The purpose of this study is to perform a systematic review and meta-analysis of randomized controlled trials and sensitivity analysis of observational studies to determine the impact of PSSE on outcomes for AIS.

METHODS

A systematic review and meta-analysis on impact of PSSE for patients with AIS was performed. Databases used included PubMed, CINAHL, MEDLINE, Cochrane, and ScienceDirect database inception to October 2022. Inclusion criteria included use of PSSE, patient population of AIS, and full text.

RESULTS

A total of 26 articles out of 628 initial retrieved met final inclusion criteria (10 randomized controlled trials (RCTs), 16 observational studies). Total included patients (n = 2083) had a frequency weighted mean age of 13.2 ± 0.9 years and a frequency weighted mean follow-up of 14.5 ± 20.0 months. Based on only data from RCTs with direct comparison groups (n = 7 articles), there was a statistically significant but clinically insignificant improvement in Cobb angle of 2.5 degrees in the PSSE group (n = 152) as compared to the control group (n = 148; p = 0.017). There was no statistically significant improvement in Cobb angle when stratified by small curve (< 30 degrees) or large curve (> 30 degrees) with PSSE (p = 0.140 and p = 0.142, respectively). There was no statistically significant improvement in ATR (p = 0.326) or SRS-22 score (p = 0.370).

CONCLUSION

PSSE may not provide any clinically significant improvements in Cobb angle, ATR, or SRS-22 scores in patients with AIS. PSSE did not significantly improve Cobb angle when stratified by curve size.

LEVEL OF EVIDENCE

Level I.

摘要

目的

青少年特发性脊柱侧凸(AIS)是一种常见的儿科脊柱畸形,常采用患者特异性脊柱侧弯运动(PSSE)进行治疗。本研究旨在对随机对照试验进行系统评价和荟萃分析,并对观察性研究进行敏感性分析,以确定 PSSE 对 AIS 患者结局的影响。

方法

对 PSSE 治疗 AIS 患者的影响进行了系统评价和荟萃分析。使用的数据库包括 PubMed、CINAHL、MEDLINE、Cochrane 和 ScienceDirect 数据库,检索时间截至 2022 年 10 月。纳入标准包括使用 PSSE、AIS 患者人群和全文。

结果

在最初检索到的 628 篇文章中,共有 26 篇文章符合最终纳入标准(10 项随机对照试验(RCTs),16 项观察性研究)。总纳入患者(n=2083)的加权平均年龄为 13.2±0.9 岁,加权平均随访时间为 14.5±20.0 个月。仅基于具有直接比较组的 RCT 数据(n=7 篇文章),PSSE 组(n=152)的 Cobb 角有统计学显著但临床无意义的 2.5 度改善,而对照组(n=148;p=0.017)。按 PSSE 治疗的小角度(<30 度)或大角度(>30 度)曲线分层,Cobb 角无统计学显著改善(p=0.140 和 p=0.142)。ATR(p=0.326)或 SRS-22 评分(p=0.370)无统计学显著改善。

结论

PSSE 可能不会为 AIS 患者的 Cobb 角、ATR 或 SRS-22 评分提供任何临床显著改善。按曲线大小分层,PSSE 并未显著改善 Cobb 角。

证据水平

I 级。

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