LC-MS/MS 法测定 PTH 的标准化：解决检测内变异性的有前途的方法。
Standardization of PTH measurement by LC-MS/MS: a promising solution for interassay variability.
机构信息
Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.
Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan; Interactive Translational Research Center for Kidney Diseases, Tokai University School of Medicine, Isehara, Japan; The Institute of Medical Sciences, Tokai University, Isehara, Japan.
出版信息
Kidney Int. 2024 Feb;105(2):244-247. doi: 10.1016/j.kint.2023.11.020.
Parathyroid hormone measurement is critical in managing chronic kidney disease-mineral bone disorders. However, there are several commercially available immunoassays with interassay variability. To address this, Cavalier et al. developed standardization of parathyroid hormone measurement by establishing regression equations of each assay against the liquid chromatography coupled to tandem mass spectrometry method. The recalibration successfully reduced interassay variability, allowing for more consistent interpretation. The proposed approach may pave the way for accurate interpretation of parathyroid hormone in clinical practice.
甲状旁腺激素的测量在慢性肾脏病-矿物质和骨异常的管理中至关重要。然而，目前有几种市售的免疫分析方法存在分析内变异。为了解决这个问题，Cavalier 等人通过建立每种检测方法与液相色谱串联质谱法的回归方程，对甲状旁腺激素的测量进行了标准化。重新校准成功地降低了分析内变异，使得解释更加一致。这种方法可能为临床实践中甲状旁腺激素的准确解释铺平道路。
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