Microbiota Research Center, Istinye University, Istanbul 34010, Turkey; College of Arts and Sciences, American University of Sharjah, University City, Sharjah 26666, United Arab Emirates.
Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Cardiovascular Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Life Sci Space Res (Amst). 2024 Feb;40:89-96. doi: 10.1016/j.lssr.2023.09.003. Epub 2023 Sep 9.
In view of the critical role the gut microbiome plays in human health, it has become clear that astronauts' gut microbiota composition changes after spending time in space. Astronauts are exposed to several risks in space, including a protracted period of microgravity, radiation, and mechanical unloading of the body. Several deleterious effects of such an environment are reported, including orthostatic intolerance, cardiovascular endothelial dysfunction, cellular and molecular changes, and changes in the composition of the gut microbiome. Herein, the correlation between the gut microbiome and cardiovascular disease in a microgravity environment is evaluated. Additionally, the relationship between orthostatic hypotension, cardiac shrinkage and arrhythmias during spaceflight, and cellular alterations during spaceflight is reviewed. Given its impact on human health in general, modifying the gut microbiota may significantly promote astronaut health and performance. This is merited, given the prospect of augmented human activities in future space missions.
鉴于肠道微生物组在人类健康中起着至关重要的作用，很明显，宇航员在太空中停留一段时间后，其肠道微生物组的组成会发生变化。宇航员在太空中会面临多种风险，包括长时间的微重力、辐射和身体的机械卸载。据报道，这种环境会产生多种有害影响，包括直立不耐受、心血管内皮功能障碍、细胞和分子变化以及肠道微生物组组成的变化。在此，评估了微重力环境中肠道微生物组与心血管疾病之间的相关性。此外，还回顾了在太空飞行期间直立性低血压、心脏收缩和心律失常以及太空飞行期间细胞变化之间的关系。鉴于其对人类健康的普遍影响，改变肠道微生物组可能会显著促进宇航员的健康和表现。鉴于未来太空任务中人类活动的增加，这是值得的。
