Department of Medicine, University of Cincinnati Medical Center, 200 Eden Avenue, Cincinnati, OH 45219, USA.
Department of Medicine, University of Cincinnati Medical Center, 200 Eden Avenue, Cincinnati, OH 45219, USA.
Clin Chest Med. 2024 Mar;45(1):119-129. doi: 10.1016/j.ccm.2023.08.008. Epub 2023 Sep 4.
The hematologic system is frequently involved in sarcoidosis. Lymphopenia is the most common hematologic manifestation noted, although anemia and thrombocytopenia also occur. The etiology of these common manifestations can be direct granulomatous infiltration of bone marrow, lymph nodes, or spleen or related to immunologic dysfunction. Although not life threatening, these problems can lead to cytopenias requiring close monitoring in patients receiving a variety of disease treatments. The relationship between sarcoidosis and malignancy remains complex. However, some sarcoidosis patients are at increased risk for the development of malignancies, particularly lymphomas and gastrointestinal cancers. Conversely, cancer patients can experience an increase in the likelihood for the development of breast cancer and lymphomas.
血液系统经常受累于类肉瘤病。淋巴细胞减少症是最常见的血液学表现，尽管贫血和血小板减少症也会发生。这些常见表现的病因可以是骨髓、淋巴结或脾脏的直接肉芽肿浸润，也可以与免疫功能障碍有关。尽管这些问题不会危及生命，但它们可能导致接受各种疾病治疗的患者出现需要密切监测的细胞减少症。类肉瘤病和恶性肿瘤之间的关系仍然很复杂。然而，一些类肉瘤病患者发生恶性肿瘤的风险增加，特别是淋巴瘤和胃肠道癌症。相反，癌症患者发生乳腺癌和淋巴瘤的可能性增加。
