Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands; Division of Heart and Lungs, University Medical Center, Utrecht, The Netherlands.
Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.
Clin Chest Med. 2024 Mar;45(1):33-43. doi: 10.1016/j.ccm.2023.09.002. Epub 2023 Oct 11.
At present, no biomarker exists which is truly specific for sarcoidosis and the ones available have modest sensitivity and specificity. The clinical context should dictate the choice of biomarker(s) used to address different clinical questions such as diagnosis, monitoring disease activity or monitoring response to treatment. In the future, in addition to known serum biomarkers, it seems fruitful to further explore a possible role of imaging, exhaled air and even biopsy-related biomarkers in sarcoidosis to guide clinical management.
目前，尚无真正特异性针对结节病的生物标志物，现有的生物标志物敏感性和特异性均不高。临床情况应决定用于解决不同临床问题（如诊断、监测疾病活动或监测治疗反应）的生物标志物（多个）的选择。未来，除了已知的血清生物标志物外，进一步探索成像、呼气和甚至活检相关生物标志物在结节病中的可能作用，以指导临床管理，似乎是富有成效的。
