Zhang Sheng, Lv Kebing, Liu Zhen, Zhao Ran, Li Fei
Center of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Jiangxi Clinical Research Center for Hematologic Disease, Nanchang, China.
Cell Death Discov. 2024 Jan 20;10(1):39. doi: 10.1038/s41420-024-01807-9.
Metabolic competition between tumour cells and immune cells for limited nutrients is an important feature of the tumour microenvironment (TME) and is closely related to the outcome of tumour immune escape. A large number of studies have proven that tumour cells need metabolic reprogramming to cope with acidification and hypoxia in the TME while increasing energy uptake to support their survival. Among them, synthesis, oxidation and uptake of fatty acids (FAs) in the TME are important manifestations of lipid metabolic adaptation. Although different immune cell subsets often show different metabolic characteristics, various immune cell functions are closely related to fatty acids, including providing energy, providing synthetic materials and transmitting signals. In the face of the current situation of poor therapeutic effects of tumour immunotherapy, combined application of targeted immune cell fatty acid metabolism seems to have good therapeutic potential, which is blocked at immune checkpoints. Combined application of adoptive cell therapy and cancer vaccines is reflected. Therefore, it is of great interest to explore the role of fatty acid metabolism in immune cells to discover new strategies for tumour immunotherapy and improve anti-tumour immunity.
肿瘤细胞与免疫细胞之间针对有限营养物质的代谢竞争是肿瘤微环境（TME）的一个重要特征，并且与肿瘤免疫逃逸的结果密切相关。大量研究已经证明，肿瘤细胞需要进行代谢重编程以应对TME中的酸化和缺氧，同时增加能量摄取以维持其存活。其中，TME中脂肪酸（FAs）的合成、氧化和摄取是脂质代谢适应的重要表现。尽管不同的免疫细胞亚群通常表现出不同的代谢特征，但各种免疫细胞功能都与脂肪酸密切相关，包括提供能量、提供合成材料和传递信号。面对当前肿瘤免疫治疗效果不佳的现状，联合应用靶向免疫细胞脂肪酸代谢似乎具有良好的治疗潜力，这在免疫检查点受到阻碍。体现了过继性细胞疗法和癌症疫苗的联合应用。因此，探索脂肪酸代谢在免疫细胞中的作用以发现肿瘤免疫治疗的新策略并提高抗肿瘤免疫力具有极大的意义。
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