PLT012，一种人源化抗CD36抗体，对释放针对肝癌和肝转移的抗肿瘤免疫有效。
PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis.
作者信息
Tzeng Sheue-Fen, Yu Yi-Ru, Park Jaeoh, von Renesse Janusz, Hsiao Huey-Wen, Hsu Chen-Hsuan, Garnica Josep, Chen Jintian, Chiu Lu-Ting, Santol Jonas, Chen Tse-Yu, Chung Pei-Han, Kandalaft Lana E, Starlinger Patrick, Hsieh Rodney Cheng-En, Yu Ming-Chin, Hsiao Pei-Wen, Carmona Santiago J, Chen Hung-Kai, Meng Zhen, Lin Yun-Han, Zhou Jingying, Tsai Chin-Hsien, Ho Ping-Chih
机构信息
Tumor Immune Analysis Core, Office of Research & Development, Taipei Medical University, Taipei, Taiwan.
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
出版信息
Cancer Discov. 2025 Apr 28:OF1-OF21. doi: 10.1158/2159-8290.CD-24-1409.
Abstract
Despite the success of cancer immunotherapies, like immune checkpoint inhibitors, many patients still fail to demonstrate significant responses because of metabolic constraints in tumors. PLT012 rejuvenates antitumor immunity by targeting metabolic pathways to reprogram the immune landscape of liver cancer and liver metastasis, with potential to influence future HCC immunotherapy.
摘要
尽管癌症免疫疗法取得了成功，如免疫检查点抑制剂，但由于肿瘤中的代谢限制，许多患者仍未能表现出显著反应。PLT012通过靶向代谢途径来重塑肝癌和肝转移的免疫格局，从而恢复抗肿瘤免疫力，有可能影响未来的肝癌免疫治疗。
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