Wang Yue, Guo Zongjin, Isah Adamu Danbala, Chen Shuangwei, Ren Yongfei, Cai Huazhong
School of Medicine, Jiangsu University, Zhenjiang, China.
Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Front Cell Dev Biol. 2023 May 16;11:1187989. doi: 10.3389/fcell.2023.1187989. eCollection 2023.
In recent years, the relationship between lipid metabolism and tumour immunotherapy has been thoroughly investigated. An increasing number of studies have shown that abnormal gene expression and ectopic levels of metabolites related to fatty acid synthesis or fatty acid oxidation affect tumour metastasis, recurrence, and drug resistance. Tumour immunotherapy that aims to promote an antitumour immune response has greatly improved the outcomes for tumour patients. However, lipid metabolism reprogramming in tumour cells or tumour microenvironment-infiltrating immune cells can influence the antitumour response of immune cells and induce tumor cell immune evasion. The recent increase in the prevalence of obesity-related cancers has drawn attention to the fact that obesity increases fatty acid oxidation in cancer cells and suppresses the activation of immune cells, thereby weakening antitumour immunity. This article reviews the changes in lipid metabolism in cells in the tumour microenvironment and describes the relationship between lipid metabolism reprogramming in multiple cell types and tumour immunotherapy.
近年来，脂质代谢与肿瘤免疫治疗之间的关系已得到深入研究。越来越多的研究表明，与脂肪酸合成或脂肪酸氧化相关的基因表达异常和代谢物异位水平会影响肿瘤转移、复发和耐药性。旨在促进抗肿瘤免疫反应的肿瘤免疫治疗极大地改善了肿瘤患者的治疗效果。然而，肿瘤细胞或肿瘤微环境浸润免疫细胞中的脂质代谢重编程会影响免疫细胞的抗肿瘤反应，并诱导肿瘤细胞免疫逃逸。最近肥胖相关癌症患病率的上升引起了人们对肥胖会增加癌细胞脂肪酸氧化并抑制免疫细胞激活从而削弱抗肿瘤免疫力这一事实的关注。本文综述了肿瘤微环境中细胞脂质代谢的变化，并描述了多种细胞类型中脂质代谢重编程与肿瘤免疫治疗之间的关系。
