Graduate Program in Nursing, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
BMC Pregnancy Childbirth. 2024 Jan 20;24(1):71. doi: 10.1186/s12884-023-06235-8.
Pregnant women with hypertensive disorders are at increased risk for inflammatory diseases and oxidative stress. The dilemma raised by the best dosage of calcium supplementation on these factors is evident. The aim of the current study was to examine the effects of calcium on biomarkers of the purinergic system, inflammation and oxidative stress, which are factors contributing to vascular damage in pregnant women at high risk of pre-eclampsia.
A prospective, double-blind and placebo-controlled study conducted with 101 women at risk of pre-eclampsia were randomized to take 500 mg calcium/day or 1,500 mg calcium/day or placebo for 6 weeks from the 20th gestational week until delivery. Fasting blood samples were collected at the beginning of the study and 6 weeks after the intervention.
Taking calcium supplements (500 mg calcium/day) led to a significant increase in ATP hydrolysis (p < 0.05), NTPDase activity with increased hydrolysis of ADP and AMP nucleotides in platelets and lymphocytes. In the intragroup analysis IL-2, IL-6, IL-4 and interferon-ɣ presented lower values in the calcium 1,500 mg/day group (p < 0.005). Oxidative stress was assessed by TBARS pro-oxidant marker, with an increase for the calcium groups when compared to the placebo group. The Vitamin C antioxidant marker presented a significant increase (p < 0.005) for the group that received high calcium doses.
Calcium administration for 6 weeks had antioxidant action and positively modulated the purinergic system and inflammatory markers in pregnant women at risk of pre-eclampsia.
患有高血压疾病的孕妇发生炎症和氧化应激的风险增加。补充钙的最佳剂量对这些因素的影响存在争议。本研究旨在观察钙对嘌呤能系统、炎症和氧化应激生物标志物的影响，这些因素是导致子痫前期高危孕妇血管损伤的原因。
对 101 例子痫前期高危孕妇进行前瞻性、双盲、安慰剂对照研究，随机分为三组，分别每天服用 500mg 钙、1500mg 钙或安慰剂，从妊娠 20 周开始干预 6 周直至分娩。在研究开始和干预 6 周后采集空腹血样。
服用钙补充剂（500mg 钙/天）可显著增加血小板和淋巴细胞中 ATP 水解（p<0.05）、NTPDase 活性及 ADP 和 AMP 核苷酸的水解。在组内分析中，1500mg 钙/天组的白细胞介素 2、白细胞介素 6、白细胞介素 4 和干扰素-γ值较低（p<0.005）。通过 TBARS 促氧化剂标志物评估氧化应激，与安慰剂组相比，钙组的氧化应激增加。高剂量钙组的维生素 C 抗氧化标志物显著增加（p<0.005）。
钙补充 6 周具有抗氧化作用，并能积极调节子痫前期高危孕妇的嘌呤能系统和炎症标志物。
