Guo Xinyue, Xu Licheng, Nie Luan, Zhang Chenyu, Liu Yaohui, Zhao Rui, Cao Jing, Tian Linli, Liu Ming
Department of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Cancer Cell Int. 2024 Jan 20;24(1):41. doi: 10.1186/s12935-024-03218-3.
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patients with poor prognoses still exist due to loss of surgical opportunities, postoperative recurrence, and metastasis, among other reasons. The tumour microenvironment (TME) is a complex organization composed of tumour, stromal, and endothelial cells. Communication and interaction between tumours and immune cells within the TME are increasingly being recognized as pivotal in inhibiting or promoting tumour development. Previous studies on T cells in the TME of HNSCC have yielded novel therapeutic possibilities. However, the function of B cells, another adaptive immune cell type, in the TME of HNSCC patients has yet to be determined. Recent studies have revealed various distinct subtypes of B cells and tertiary lymphoid structures (TLSs) in the TME of HNSCC patients, which are believed to impact the efficacy of immune checkpoint inhibitors (ICIs). Therefore, this paper focuses on B cells in the TME to explore potential directions for future immunotherapy for HNSCC.
头颈部鳞状细胞癌（HNSCC）是一种常见的恶性肿瘤。尽管手术、放疗和化疗取得了进展，改善了大多数患者的预后，但由于手术机会丧失、术后复发和转移等原因，仍有一部分预后较差的患者。肿瘤微环境（TME）是一个由肿瘤细胞、基质细胞和内皮细胞组成的复杂组织。肿瘤微环境中肿瘤与免疫细胞之间的通讯和相互作用越来越被认为在抑制或促进肿瘤发展中起关键作用。先前关于HNSCC肿瘤微环境中T细胞的研究产生了新的治疗可能性。然而，另一种适应性免疫细胞类型B细胞在HNSCC患者肿瘤微环境中的功能尚未确定。最近的研究揭示了HNSCC患者肿瘤微环境中各种不同的B细胞亚型和三级淋巴结构（TLSs），据信它们会影响免疫检查点抑制剂（ICIs）的疗效。因此，本文聚焦于肿瘤微环境中的B细胞，以探索HNSCC未来免疫治疗的潜在方向。
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