Preston P M
Trans R Soc Trop Med Hyg. 1979;73(2):212-5. doi: 10.1016/0035-9203(79)90215-3.
Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.
鼠麻风分枝杆菌在近交系小鼠中的不同感染模式作为研究人类分枝杆菌感染（如麻风分枝杆菌，其会呈现一系列临床疾病）的模型系统备受关注。在体外，来自抗性（C57B1）和易感（BALB/c）近交系小鼠的巨噬细胞在控制鼠麻风分枝杆菌增殖方面表现出同等效力。此处呈现的实验表明，在体内，易感（BALB/c）品系小鼠中巨噬细胞介导的免疫潜在机制会被感染小鼠血清和腹膜液中存在的一种或多种可溶性因子所抑制。
