在易感小鼠中诱导针对鼠麻风杆菌的细胞介导免疫。
Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice.
作者信息
Lefford M J, Patel P J, Poulter L W, Mackaness G B
出版信息
Infect Immun. 1977 Dec;18(3):654-9. doi: 10.1128/iai.18.3.654-659.1977.
Abstract
A mouse strain (CB6) that is highly susceptible to Mycobacterium lepraemurium was infected with 10(8) bacilli into the hind footpad. These mice developed cell-mediated immunity to M. lepraemurium, as expressed by the development of a granulomatous lesion at the site of inoculation in normal but not in T-lymphocyte-depleted mice, a proliferative response in the paracortical zone of the draining lymph node, delayed-type hypersensitivity to a sonic extract of M. lepraemurium, and immunopotentiation of the delayed hypersensitivity response to sheep erythrocytes. Resistance to a second challenge infection with M. lepraemurium was not demonstrated.
摘要
一种对鼠麻风杆菌高度易感的小鼠品系（CB6），通过后足垫接种10⁸个杆菌进行感染。这些小鼠对鼠麻风杆菌产生了细胞介导的免疫，表现为在正常小鼠而非T淋巴细胞耗竭的小鼠接种部位出现肉芽肿性病变、引流淋巴结副皮质区的增殖反应、对鼠麻风杆菌超声提取物的迟发型超敏反应以及对绵羊红细胞迟发型超敏反应的免疫增强。但未证明对第二次鼠麻风杆菌攻击感染具有抵抗力。
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