Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
J Pharmacol Sci. 2024 Feb;154(2):47-51. doi: 10.1016/j.jphs.2023.12.001. Epub 2023 Dec 7.
Goreisan is a Kampo medicine used to treat headaches associated with climate change. Here, by using an implantable complementary metal-oxide-semiconductor (CMOS) device, we evaluated the effects of Goreisan and loxoprofen on cerebral blood flow (CBF) dynamics associated with barometric pressure fluctuations in freely moving mice. In the vehicle group, decreasing barometric pressure increased CBF that was prevented by Goreisan and loxoprofen. Notably, Goreisan, but not loxoprofen, reduced CBF after returning to atmospheric pressure. These results indicate that, unlike the mechanism of action of antipyretic analgesics, Goreisan normalizes CBF abnormalities associated with barometric pressure fluctuations by actively reducing CBF increase.
葛根汤是一种汉方药，用于治疗与气候变化相关的头痛。在这里，我们使用一种可植入的互补金属氧化物半导体（CMOS）设备，评估了葛根汤和洛索洛芬对自由活动小鼠气压波动相关脑血流（CBF）动力学的影响。在载体组中，气压下降会增加 CBF，而葛根汤和洛索洛芬可预防这种增加。值得注意的是，葛根汤可降低气压恢复后 CBF，而洛索洛芬则没有。这些结果表明，与解热镇痛药的作用机制不同，葛根汤通过主动降低 CBF 增加来使与气压波动相关的 CBF 异常正常化。
