血栓素A2抑制对肾积水性萎缩发展的影响。
Influence of thromboxane A2 inhibition on the development of hydronephrotic atrophy.
作者信息
Huland H, Brenger B, Gonnermann D, Schäfer H
出版信息
Urol Int. 1986;41(6):422-5. doi: 10.1159/000281247.
PMID:3824698
Abstract
The development of hydronephrotic atrophy as measured by dry and wet weight in relation to wholebody weight, in rats after complete unilateral ureteral obstruction could be influenced by oral administration of OKY 1581, an inhibitor of thromboxane A2 synthesis. The data are consistent with the thesis that preglomerular thromboxane A2-mediated active vasoconstriction is involved, most likely by ischemia, in the development of hydronephrotic atrophy, at least in the renal cortex.
摘要
通过干湿重量与体重的关系来衡量，在大鼠完全性单侧输尿管梗阻后，肾积水性萎缩的发展可能会受到口服血栓素A2合成抑制剂OKY 1581的影响。这些数据与以下论点一致，即至少在肾皮质中，肾前性血栓素A2介导的主动血管收缩最有可能通过缺血参与了肾积水性萎缩的发展。
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