Loo M H, Marion D N, Vaughan E D, Felsen D, Albanese C T
J Urol. 1986 Dec;136(6):1343-7. doi: 10.1016/s0022-5347(17)45334-1.
The effect of the thromboxane synthetase inhibitor OKY-046 on renal blood flow and ureteral pressure in awake dogs during 18 hours of complete unilateral ureteral obstruction was studied. OKY-046 was infused continuously throughout the period of obstruction and post-release. Renal blood flow and ureteral pressure were constantly monitored during the study. Urinary thromboxane B2 and prostaglandin E2 excretion served as markers for inhibition of renal thromboxane A2 synthesis. The triphasic relationship between ipsilateral renal blood flow and ureteral pressure previously found following unilateral ureteral obstruction was observed despite OKY-046 infusion. Inhibition of ipsilateral urinary thromboxane B2 excretion was greater than 90% compared to control while ipsilateral urinary prostaglandin E2 excretion was not consistently decreased showing specific thromboxane inhibition. These results suggest that urinary thromboxane B2 may serve as a useful marker for determining the effects of inhibition on renal thromboxane A2 production. At the level of inhibition of thromboxane synthesis achieved we did not observe any change in the late decrease in renal blood flow which is typically seen with chronic unilateral ureteral obstruction.
研究了血栓素合成酶抑制剂OKY - 046对清醒犬单侧输尿管完全梗阻18小时期间肾血流量和输尿管压力的影响。在梗阻期和解除梗阻后持续输注OKY - 046。研究期间持续监测肾血流量和输尿管压力。尿血栓素B2和前列腺素E2排泄量作为肾血栓素A2合成受抑制的标志物。尽管输注了OKY - 046，但仍观察到单侧输尿管梗阻后同侧肾血流量与输尿管压力之间先前发现的三相关系。与对照组相比，同侧尿血栓素B2排泄量的抑制率大于90%，而同侧尿前列腺素E2排泄量并未持续降低，显示出特异性血栓素抑制作用。这些结果表明，尿血栓素B2可能是确定抑制肾血栓素A2产生效果的有用标志物。在达到的血栓素合成抑制水平上，我们未观察到慢性单侧输尿管梗阻时通常出现的肾血流量后期下降有任何变化。
