Guitteny Sacha, Lee Cadence F, Amirouche Farid
Department of Orthopaedic Surgery, University of Illinois College of Medicine at Chicago, Chicago, IL 60607, USA.
Orthopaedic and Spine Institute, NorthShore University Health System, Chicago, IL 60611, USA.
Bioengineering (Basel). 2024 Jan 18;11(1):96. doi: 10.3390/bioengineering11010096.
Vertebral compression fractures (VCFs) occur in 1 to 1.5 million patients in the US each year and are associated with pain, disability, altered pulmonary function, secondary vertebral fracture, and increased mortality risk. A better understanding of VCFs and their management requires preclinical models that are both biomechanically analogous and accessible. We conducted a study using twelve spinal vertebrae (T12-T14) from porcine specimens. We created mathematical simulations of vertebral compression fractures (VCFs) using CT scans for reconstructing native anatomy and validated the results by conducting physical axial compression experiments. The simulations accurately predicted the behavior of the physical compressions. The coefficient of determination for stiffness was 0.71, the strength correlation was 0.88, and the failure of the vertebral bodies included vertical splitting on the lateral sides or horizontal separation in the anterior wall. This finite element method has important implications for the preventative, prognostic, and therapeutic management of VCFs. This study also supports the use of porcine specimens in orthopedic biomechanical research.
在美国，每年有100万至150万患者发生椎体压缩骨折（VCF），这些骨折与疼痛、残疾、肺功能改变、继发性椎体骨折以及死亡风险增加有关。要更好地了解VCF及其治疗方法，需要具备生物力学相似性且易于获取的临床前模型。我们使用了来自猪标本的12个脊椎（T12 - T14）进行了一项研究。我们利用CT扫描创建了椎体压缩骨折（VCF）的数学模拟，以重建原始解剖结构，并通过进行物理轴向压缩实验验证了结果。模拟准确地预测了物理压缩的行为。刚度的决定系数为0.71，强度相关性为0.88，椎体的破坏包括侧面的垂直分裂或前壁的水平分离。这种有限元方法对VCF的预防、预后和治疗管理具有重要意义。这项研究还支持在骨科生物力学研究中使用猪标本。
