Shapkin A G
Vestn Khir Im I I Grek. 1986 Dec;137(12):50-6.
On the model of focal-caseous tuberculosis of kidneys in 210 rabbits it was proved that effects of antibacterial drugs in any concentration have their limits and fail to liquidate the cavernous injuries of the renal parenchyma. The investigation of long-term results of the conservative treatment of 153 patients with the cavernous tuberculosis of kidneys has completely confirmed the conclusions of experimental investigations. An analysis of long-term results of organ-preserving focal operations in experiments and clinic gave a substantial support to a real possibility to cure the pathological process. The author points to an importance to revise the idea of the leading role of the conservative antibacterial therapy in favor of wider using radical-prophylactic operations in limited cavernous tuberculosis of kidneys.
在210只家兔的局灶性干酪样肾结核模型上证实，任何浓度的抗菌药物的作用都有其局限性，无法消除肾实质的空洞性损伤。对153例肾空洞性结核患者保守治疗的长期结果进行的研究完全证实了实验研究的结论。对实验和临床中保留器官的局灶性手术的长期结果进行分析，为治愈病理过程的实际可能性提供了有力支持。作者指出，有必要修正保守抗菌治疗起主导作用的观念，转而在局限性肾空洞性结核中更广泛地采用根治性预防性手术。
