大鼠脑膜的自发性肿瘤

Spontaneous tumors of the meninges in rats.

作者信息

Mitsumori K, Maronpot R R, Boorman G A

出版信息

Vet Pathol. 1987 Jan;24(1):50-8. doi: 10.1177/030098588702400109.

Abstract

Histologic brain sections from 107 rats reported to have granular cell tumors or meningiomas in 2-year carcinogenicity studies conducted by the National Toxicology Program (NTP) or the National Cancer Institute (NCI) were reexamined microscopically. There were 62 rats with granular cell tumors, 26 with benign meningiomas, and 19 with meningeal sarcomas. Granular cell tumors were compatible with previous descriptions of this tumor. Meningeal sarcomas were subclassified into nine spindle cell sarcomas and ten fibrosarcomas. Among the rats with benign meningiomas, five were typical meningiomas (three fibroblastic meningiomas, and two meningothelial meningiomas) and 21 were meningothelial meningiomas containing cells with granules identical to those in granular cell tumors. There was a transition from epithelial-like cells of the meningothelial meningiomas to granular cells in these 21 cases. Based upon anatomic location, cytomorphologic similarities, and the occurrence of transitional or mixed forms of meningothelial meningiomas and granular cell tumors, it is suggested that these two tumors are related and may both originate from a common progenitor meningothelial arachnoid cell.

摘要

对107只大鼠的脑组织切片进行了显微镜复查，这些大鼠在国家毒理学计划（NTP）或美国国立癌症研究所（NCI）开展的两年致癌性研究中被报告患有颗粒细胞瘤或脑膜瘤。其中有62只大鼠患有颗粒细胞瘤，26只患有良性脑膜瘤，19只患有脑膜肉瘤。颗粒细胞瘤与此前对该肿瘤的描述相符。脑膜肉瘤被进一步细分为9例梭形细胞肉瘤和10例纤维肉瘤。在患有良性脑膜瘤的大鼠中，5例为典型脑膜瘤（3例纤维母细胞性脑膜瘤和2例脑膜内皮型脑膜瘤），21例为脑膜内皮型脑膜瘤，其所含细胞的颗粒与颗粒细胞瘤中的颗粒相同。在这21例中，存在从脑膜内皮型脑膜瘤的上皮样细胞向颗粒细胞的转变。基于解剖位置、细胞形态学相似性以及脑膜内皮型脑膜瘤和颗粒细胞瘤过渡或混合形式的出现，提示这两种肿瘤相关，且可能均起源于共同的祖细胞——脑膜蛛网膜细胞。