Kopel Hagit, Bogdanov Alina, Winer-Jones Jessamine P, Adams Christopher, Winer Isabelle H, Bonafede Machaon, Nguyen Van Hung, Mansi James A
Moderna, Inc., Cambridge, MA 02139, USA.
Veradigm, Chicago, IL 60654, USA.
Diseases. 2024 Jan 3;12(1):16. doi: 10.3390/diseases12010016.
Influenza and COVID-19 contribute significantly to the infectious disease burden during the respiratory season, but their relative burden remains unknown. This study characterizes the frequency and severity of medically attended COVID-19 and influenza during the peak of the 2022-2023 influenza season in the pediatric, adult, and older adult populations and characterizes the prevalence of underlying conditions among patients hospitalized with COVID-19. This cross-sectional analysis included individuals in the Veradigm EHR Database linked to Komodo claims data with a medical encounter between 1 October 2022 and 31 March 2023 (study period). Patients with medical encounters were identified with a diagnosis of COVID-19 or influenza during the study period and stratified based on the highest level of care received with that diagnosis. Among 23,526,196 individuals, there were more COVID-19-related medical encounters than influenza-related encounters, overall and by outcome. Hospitalizations with COVID-19 were more common than hospitalizations with influenza overall (incidence ratio = 4.6) and in all age groups. Nearly all adults hospitalized with COVID-19 had at least one underlying medical condition, but 37.1% of 0-5-year-olds and 25.0% of 6-17-year-olds had no underlying medical conditions. COVID-19 was associated greater burden than influenza during the peak of the 2022-2023 influenza season.
流感和新冠病毒对呼吸道疾病流行季节的传染病负担有重大影响，但其相对负担仍不明确。本研究描述了2022 - 2023年流感季节高峰期儿科、成人和老年人群中因新冠病毒和流感就医的频率和严重程度，并描述了新冠病毒住院患者潜在疾病的患病率。这项横断面分析纳入了Veradigm电子健康记录数据库中与科莫多理赔数据相关联的个体，这些个体在2022年10月1日至2023年3月31日（研究期间）有过医疗接触。研究期间确定有新冠病毒或流感诊断的有医疗接触的患者，并根据该诊断所接受的最高护理级别进行分层。在23,526,196名个体中，总体及按结果来看，与新冠病毒相关的医疗接触比与流感相关的接触更多。总体而言（发病率比 = 4.6）以及在所有年龄组中，新冠病毒住院比流感住院更常见。几乎所有因新冠病毒住院的成年人都至少有一种基础疾病，但0至5岁儿童中有37.1%、6至17岁儿童中有25.0%没有基础疾病。在2022 - 2023年流感季节高峰期，新冠病毒造成的负担比流感更大。
