抗磷脂综合征中的中风及危险因素
Stroke and Risk Factors in Antiphospholipid Syndrome.
作者信息
Fan Yangyi, Xu Yicheng, Zhang Sifan, Song Xiaodong, Liu Zunjing, Tu Wenjun, Li Chun
机构信息
Department of Neurology, Peking University People's Hospital, Beijing 100044, China.
Department of Neurology, Aerospace Center Hospital, Beijing 100049, China.
出版信息
J Pers Med. 2023 Dec 24;14(1):24. doi: 10.3390/jpm14010024.
Stroke is considered one of the most common and life-threatening manifestations of antiphospholipid syndrome (APS), which leads to high mortality and permanent disability. This study investigated the prevalence and the potential risk factors of stroke in APS. We enrolled 361 APS patients retrospectively from 2009 to 2022 at Peking University People's Hospital. Stroke was found in 25.8% (93/361) of the participants. The multivariate logistic regression showed that hypertension, diabetes, livedo reticularis, and other central nervous system involvements were significant related factors for stroke. The use of hydroxychloroquine appeared to relate to a lower incidence of stroke. During a median follow-up of 3.0 years, 11.8% (11/93) of the individuals with a previous stroke developed stroke recurrence, and thrombocytopenia seemed to be a predictor of stroke recurrence.
中风被认为是抗磷脂综合征（APS）最常见且危及生命的表现之一，会导致高死亡率和永久性残疾。本研究调查了APS患者中风的患病率及潜在危险因素。我们于2009年至2022年在北京大学人民医院对361例APS患者进行了回顾性研究。在参与者中发现25.8%（93/361）患有中风。多因素逻辑回归显示，高血压、糖尿病、网状青斑和其他中枢神经系统受累是中风的显著相关因素。使用羟氯喹似乎与中风发生率较低有关。在中位随访3.0年期间，既往有中风的个体中有11.8%（11/93）发生中风复发，血小板减少似乎是中风复发的一个预测因素。
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