Kahraman Çetin Nesibe, Taşan Sinan Can
Department of Pathology, Faculty of Medicine, Aydın Adnan Menderes University, 09010 Aydın, Turkey.
J Pers Med. 2024 Jan 15;14(1):95. doi: 10.3390/jpm14010095.
Nowadays, the aging human population exerts a notable influence on the treatment of thyroid diseases. The most appropriate approach for the treatment of benign and malignant thyroid diseases in older adults has not yet been determined. The aim of our study is to evaluate the effect of thyroidectomies in geriatric patients considering age, sex and histopathological parameters and to determine the importance of thyroidectomy as a treatment option in the geriatric population. A total of 910 cases from all age groups were included, for which thyroidectomies were examined and reported. In accordance with the College of American Pathologists Cancer Protocol for thyroid reporting, considering geriatric patients, the rate of Thyroid Follicular Nodular Disease was significantly higher among the tumor types in the benign tumor group ( = 0.033), while Anaplastic Thyroid Carcinoma rate was higher in the malignant tumor group. The diagnosis rate of malignant tumors was higher in males, reflecting a more advanced pT stage ( < 0.001), larger tumor size ( < 0.001) and increased lymph node involvement rate ( = 0.039). Given that increasing age is associated with a heightened incidence of thyroid disease, the safety of surgery for geriatric patients is an important issue. Thyroidectomy should be considered in the treatment of these patients, especially in males, as the rate of malignant diagnosis and worse histopathological parameters are seen with increasing age.
如今,人口老龄化对甲状腺疾病的治疗产生了显著影响。老年患者良性和恶性甲状腺疾病的最佳治疗方法尚未确定。我们研究的目的是评估甲状腺切除术对老年患者的影响,考虑年龄、性别和组织病理学参数,并确定甲状腺切除术作为老年人群治疗选择的重要性。总共纳入了来自所有年龄组的910例病例,对其甲状腺切除术进行了检查和报告。根据美国病理学家协会甲状腺报告癌症协议,考虑到老年患者,良性肿瘤组中甲状腺滤泡结节病的发生率在肿瘤类型中显著更高(=0.033),而恶性肿瘤组中未分化甲状腺癌的发生率更高。男性恶性肿瘤的诊断率更高,反映出pT分期更晚(<0.001)、肿瘤尺寸更大(<0.001)以及淋巴结受累率增加(=0.039)。鉴于年龄增长与甲状腺疾病发病率升高相关,老年患者手术的安全性是一个重要问题。在这些患者的治疗中应考虑甲状腺切除术,尤其是男性患者,因为随着年龄增长,恶性诊断率和更差的组织病理学参数更为常见。