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人巨细胞病毒是情绪障碍的潜在危险因素吗？一项系统评价和荟萃分析。

Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis.

作者信息

Yousefian Zahra, Tamijani Seyedeh Masoumeh Seyedhosseini, Ghazvini Hamed, Kheirkhah Farzan, Rafaiee Raheleh, Mousavi Tahoora

机构信息

Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Psychiatry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

出版信息

Indian J Psychiatry. 2023 Nov;65(11):1104-1111. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_672_23. Epub 2023 Nov 24.

DOI:10.4103/indianjpsychiatry.indianjpsychiatry_672_23
PMID:38249142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10795672/
Abstract

Mood disorders are among the common mental disorders worldwide. Because of the persistence of cytomegalovirus (CMV) in the body and nervous system, this virus can be activated when the immune system is weakened and continues to exert its destructive effects throughout life. This study aimed to investigate the seroprevalence and association of human cytomegalovirus with mood disorders. Eligible articles were extracted using online international databases Science Direct, Medline, Web of Science, Scopus, and Google Scholar between 2000 and 2023. After quality assessment and specific inclusion and exclusion criteria, a total of eight eligible articles were included in the meta-analysis. Our finding showed that the seropositivity of CMV in mood disorders was 51.6% (95% CI; 42.8-60.4). There were statistical differences between mood disorders and control groups regarding the seropositivity of CMV 1.327% (95% CI; 13.27-10.45). The results of the publication bias using the Egger test confirmed no publication bias in each sub-group. The results of this meta-analysis study demonstrated that CMV infection might have associations with the incidence of mood disorders. Furthermore, we found that there were statistical differences between mood disorders and control groups regarding the seropositivity of CMV.

摘要

情绪障碍是全球常见的精神障碍之一。由于巨细胞病毒（CMV）在体内和神经系统中持续存在，当免疫系统减弱时，这种病毒会被激活，并在一生中持续发挥其破坏作用。本研究旨在调查人类巨细胞病毒的血清流行率及其与情绪障碍的关联。通过在线国际数据库Science Direct、Medline、Web of Science、Scopus和Google Scholar，检索了2000年至2023年间符合条件的文章。经过质量评估和特定的纳入与排除标准后，共有8篇符合条件的文章被纳入荟萃分析。我们的研究结果表明，情绪障碍中CMV的血清阳性率为51.6%（95%置信区间；42.8 - 60.4）。情绪障碍组和对照组在CMV血清阳性率方面存在统计学差异，为1.327%（95%置信区间；13.27 - 10.45）。使用Egger检验的发表偏倚结果证实各亚组均无发表偏倚。这项荟萃分析研究的结果表明，CMV感染可能与情绪障碍的发病率有关。此外，我们发现情绪障碍组和对照组在CMV血清阳性率方面存在统计学差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/a21735f66c90/IJPsy-65-1104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/21977af48923/IJPsy-65-1104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/5d10761ea071/IJPsy-65-1104-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/0e5016d93acd/IJPsy-65-1104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/09de117d36eb/IJPsy-65-1104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/9eab982d92c4/IJPsy-65-1104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/a21735f66c90/IJPsy-65-1104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/21977af48923/IJPsy-65-1104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/5d10761ea071/IJPsy-65-1104-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/0e5016d93acd/IJPsy-65-1104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/09de117d36eb/IJPsy-65-1104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/9eab982d92c4/IJPsy-65-1104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a0/10795672/a21735f66c90/IJPsy-65-1104-g006.jpg

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