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一名年轻女性2型糖尿病患者后来被诊断为胰腺性糖尿病:糖尿病分类中的困境

Type 2 Diabetes Mellitus in a Young Female Later Diagnosed as​​​​ Pancreatogenic Diabetes: The Dilemma in Classifying Diabetes Mellitus.

作者信息

Lamba Mahak, Yadav Ambuj, Bhagchandani Deepak, Reddy Himanshu, Vidyarthi Vikas Chandra

机构信息

Internal Medicine, King George's Medical University, Lucknow, IND.

Internal Medicine, Gastroenterology and Hepatology, King George's Medical University, Lucknow, IND.

出版信息

Cureus. 2023 Dec 20;15(12):e50828. doi: 10.7759/cureus.50828. eCollection 2023 Dec.

Abstract

Diabetes mellitus type 3c (DM3c) is a diabetes caused by pancreatic pathology. It occurs due to the destruction of the endocrine islet cells. Diabetes diagnosed at the age of 20-30 years share a common dilemma in segregating between the type of diabetes the patient has, as its management varies depending on the type of diabetes the patient is harboring. However, insulin remains the treatment of choice in later decades as the pancreatic reserves of beta cells exhaust, although it takes decades to happen. We report a case of a woman who was diagnosed with diabetes mellitus at the age of 26, was on oral hypoglycemic agents (OHA), and was shifted to insulin therapy as she became non-responsive to OHA in a short span of six years, which was alarming. The patient presented to us with the chief complaints of recurrent abdominal pain that aggravated on taking meals and was associated with multiple episodes of vomiting for two months. Blood gas analysis on admission had no evidence of metabolic acidosis, urine ketones were negative, and a random blood sugar test (RBS:202) excluded the possibility of diabetic ketoacidosis. Serum amylase and serum lipase were within normal limits. Contrast-enhanced computed tomography (CECT) of the abdomen was suggestive of the atrophic pancreas with the non-dilated main pancreatic duct. Magnetic resonance cholangiopancreatography (MRCP) was done to rule out the congenital anomalies of the pancreas responsible for chronic pancreatitis, which showed no structural abnormalities. During our clinical workup, we postulated that the diabetes she was diagnosed with at the age of 26 was DM3c, i.e., pancreatogenic diabetes. The rapid shift of patients from OHA to subcutaneous insulin in a short span must be alarming to the physician managing diabetes and needs extensive workup to look upon the etiology of the same.

摘要

3c型糖尿病(DM3c)是一种由胰腺病变引起的糖尿病。它是由于内分泌胰岛细胞的破坏而发生的。20至30岁被诊断出患有糖尿病的患者在区分自己所患糖尿病类型时面临一个共同的难题,因为其治疗方法会因患者所患糖尿病类型的不同而有所差异。然而,随着β细胞的胰腺储备在数十年后耗尽,胰岛素仍然是首选治疗方法,尽管这需要数十年时间才会发生。我们报告了一例26岁被诊断为糖尿病的女性病例,她曾服用口服降糖药(OHA),但在短短六年内对OHA无反应后转而接受胰岛素治疗,这令人担忧。该患者向我们主诉反复腹痛,进食后加重,并伴有两个月的多次呕吐发作。入院时血气分析无代谢性酸中毒证据,尿酮体阴性,随机血糖检测(RBS:202)排除了糖尿病酮症酸中毒的可能性。血清淀粉酶和血清脂肪酶在正常范围内。腹部增强计算机断层扫描(CECT)提示胰腺萎缩,主胰管未扩张。进行磁共振胰胆管造影(MRCP)以排除导致慢性胰腺炎的胰腺先天性异常,结果显示无结构异常。在我们的临床检查过程中,我们推测她26岁时被诊断出的糖尿病是DM3c,即胰腺源性糖尿病。患者在短时间内从OHA迅速转为皮下胰岛素治疗,这肯定会让管理糖尿病的医生感到担忧,需要进行广泛的检查以查明其病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fc4/10797847/c4b4fb3ead81/cureus-0015-00000050828-i01.jpg

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