Department of Clinical Medicine, University of Bologna, Bologna, Italy.
Gastroenterology. 2010 Apr;138(4):1302-11. doi: 10.1053/j.gastro.2009.12.057. Epub 2010 Jan 13.
BACKGROUND & AIMS: Population-based endoscopic studies are needed to assess the epidemiology of functional dyspepsia (FD) and the newly suggested subgroups of meal-related symptoms and epigastric pain. We evaluated the prevalence of, and risk factors for, FD in the Italian general population.
A total of 1533 inhabitants of 2 villages were invited to undergo symptom evaluation using a validated questionnaire, esophagogastroduodenoscopy, and (13)C-urea breath test; 1033 subjects (67.4%) took part.
Of the 1033 subjects, 156 (15.1%; 95% confidence interval [CI], 12.9-17.3) had dyspepsia, and of these 114 (11%; 95% CI, 9.2-12.9) had FD. Of the 114 subjects with FD, 77 (67.5%) had meal-related symptoms (postprandial fullness and/or early satiation) and 55 (48.2%) had epigastric pain. Only 18 subjects (15.8%) had both meal-related symptoms and epigastric pain; this was fewer than expected by chance alone (P < .001). Unemployment (odds ratio [OR], 5.80; 95% CI, 1.56-21.60), divorce (OR, 2.76; 95% CI, 1.10-6.91), smoking (OR, 1.74; 95% CI, 1.11-2.70), and irritable bowel syndrome (OR, 3.38; 95% CI, 1.85-6.19) were significantly associated with FD. Unemployment, divorce, and irritable bowel syndrome were associated with both meal-related symptoms and epigastric pain, while smoking was associated only with meal-related symptoms.
FD is present in 11% of the Italian general population. Unemployment and divorce seem to increase the risk of FD, and smoking seems to be associated with meal-related symptoms. Two distinct subgroups of FD, as suggested by Rome III, seem to exist in the general population.
需要进行基于人群的内镜研究，以评估功能性消化不良（FD）的流行病学以及新提出的与进餐相关症状和上腹痛亚组。我们评估了意大利一般人群中 FD 的患病率和危险因素。
邀请 2 个村庄的 1533 名居民使用经过验证的问卷、食管胃十二指肠镜检查和（13）C-尿素呼气试验进行症状评估；1033 名受试者（67.4%）参加了研究。
在 1033 名受试者中，有 156 名（15.1%；95%置信区间 [CI]，12.9-17.3）有消化不良，其中 114 名（11%；95% CI，9.2-12.9）患有 FD。在 114 名 FD 患者中，77 名（67.5%）有与进餐相关的症状（餐后饱胀和/或早饱），55 名（48.2%）有上腹痛。只有 18 名患者（15.8%）同时有与进餐相关的症状和上腹痛；这比仅通过机会预测的要少（P<.001）。失业（比值比 [OR]，5.80；95% CI，1.56-21.60）、离婚（OR，2.76；95% CI，1.10-6.91）、吸烟（OR，1.74；95% CI，1.11-2.70）和肠易激综合征（OR，3.38；95% CI，1.85-6.19）与 FD 显著相关。失业、离婚和肠易激综合征与与进餐相关的症状和上腹痛均相关，而吸烟仅与与进餐相关的症状相关。罗马 III 提出的两个不同的 FD 亚组似乎存在于一般人群中。
