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[Not Available].

作者信息

Guo Ao, Zhang Shengting, Yang Runhuai, Sui Cong

机构信息

Department of Trauma and Pediatric Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, 231200, China.

School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.

出版信息

Mater Today Bio. 2023 Dec 30;24:100939. doi: 10.1016/j.mtbio.2023.100939. eCollection 2024 Feb.


DOI:10.1016/j.mtbio.2023.100939
PMID:38249436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10797197/
Abstract

Gelatin methacrylate (GelMA) hydrogels have gained significant traction in diverse tissue engineering applications through the utilization of 3D printing technology. As an artificial hydrogel possessing remarkable processability, GelMA has emerged as a pioneering material in the advancement of tissue engineering due to its exceptional biocompatibility and degradability. The integration of 3D printing technology facilitates the precise arrangement of cells and hydrogel materials, thereby enabling the creation of in vitro models that simulate artificial tissues suitable for transplantation. Consequently, the potential applications of GelMA in tissue engineering are further expanded. In tissue engineering applications, the mechanical properties of GelMA are often modified to overcome the hydrogel material's inherent mechanical strength limitations. This review provides a comprehensive overview of recent advancements in enhancing the mechanical properties of GelMA at the monomer, micron, and nano scales. Additionally, the diverse applications of GelMA in soft tissue engineering via 3D printing are emphasized. Furthermore, the potential opportunities and obstacles that GelMA may encounter in the field of tissue engineering are discussed. It is our contention that through ongoing technological progress, GelMA hydrogels with enhanced mechanical strength can be successfully fabricated, leading to the production of superior biological scaffolds with increased efficacy for tissue engineering purposes.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/79e3fa3e4efc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/dc74aa31d32c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/e13488734a1d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/66f04423611a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/2572fb5822dd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/5bd8e3364fc3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/f36f83857ba8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/f2312cabd552/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/79e3fa3e4efc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/dc74aa31d32c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/e13488734a1d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/66f04423611a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/2572fb5822dd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/5bd8e3364fc3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/f36f83857ba8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/f2312cabd552/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f453/10797197/79e3fa3e4efc/gr7.jpg

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[1]
[Not Available].

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本文引用的文献

[1]
Advantages of photo-curable collagen-based cell-laden bioinks compared to methacrylated gelatin (GelMA) in digital light processing (DLP) and extrusion bioprinting.

Mater Today Bio. 2023-9-16

[2]
Photo-Cross-Linkable, Injectable, and Highly Adhesive GelMA-Glycol Chitosan Hydrogels for Cartilage Repair.

Adv Healthc Mater. 2023-12

[3]
Optimization of Gelatin Methacryloyl Hydrogel Properties through an Artificial Neural Network Model.

ACS Appl Mater Interfaces. 2023-9-27

[4]
Bioactive Glasses-Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro-Healing Properties for Diabetic Infected Wound Repair.

Adv Healthc Mater. 2023-11

[5]
Portable Handheld "SkinPen" Loaded with Biomaterial Ink for In Situ Wound Healing.

ACS Appl Mater Interfaces. 2023-6-14

[6]
Bioengineering for vascularization: Trends and directions of photocrosslinkable gelatin methacrylate hydrogels.

Front Bioeng Biotechnol. 2022-11-17

[7]
Three-in-one customized bioink for islet organoid: GelMA/ECM/PRP orchestrate pro-angiogenic and immunoregulatory function.

Colloids Surf B Biointerfaces. 2023-1

[8]
Optimization of methacrylated gelatin /layered double hydroxides nanocomposite cell-laden hydrogel bioinks with high printability for 3D extrusion bioprinting.

J Biomed Mater Res A. 2023-2

[9]
Modulation of bioactive calcium phosphate micro/nanoparticle size and shape during in situ synthesis of photo-crosslinkable gelatin methacryloyl based nanocomposite hydrogels for 3D bioprinting and tissue engineering.

Biomater Res. 2022-10-8

[10]
Application of Bone Marrow-Derived Macrophages Combined with Bone Mesenchymal Stem Cells in Dual-Channel Three-Dimensional Bioprinting Scaffolds for Early Immune Regulation and Osteogenic Induction in Rat Calvarial Defects.

ACS Appl Mater Interfaces. 2022-10-19

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