Khasnavis Arpita, Fernandes Merle
Academy for Eye Care Education, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Cornea and Anterior Segment Service, Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Taiwan J Ophthalmol. 2023 Oct 20;13(4):434-442. doi: 10.4103/tjo.TJO-D-23-00065. eCollection 2023 Oct-Dec.
Peters anomaly (PA) is a rare, often bilateral, congenital corneal opacity, usually with a sporadic inheritance pattern, characterized by corneal opacities and irido-corneal or lenticular-corneal adhesions with a defect in the Descemet's membrane, occurring due to anterior segment dysgenesis during fetal development. Due to other ocular and systemic comorbidities, a team comprising pediatric cornea, glaucoma, and strabismus specialists in addition to a pediatrician and geneticist is necessary for the appropriate management of these children. Since the outcome of pediatric penetrating keratoplasty is variable and has a higher chance of failure when accompanied by additional procedures, such as lensectomy and vitrectomy, minimally invasive alternatives are increasingly being offered to these patients. Of note is the recently reported novel procedure: selective endothelialectomy for PA, which avoids the need for a corneal transplant and results in gradual clearing of the corneal opacity over time. In this overview, we aimed to describe the etiology, classification, pathophysiology, histopathology, clinical features, and management of PA.
彼得斯异常（PA）是一种罕见的、常为双侧性的先天性角膜混浊，通常呈散发性遗传模式，其特征为角膜混浊以及虹膜 - 角膜或晶状体 - 角膜粘连，伴有后弹力层缺损，这是由于胎儿发育期间眼前段发育异常所致。由于存在其他眼部和全身合并症，除儿科医生和遗传学家外，还需要一个由小儿角膜、青光眼和斜视专家组成的团队来对这些儿童进行恰当的管理。由于小儿穿透性角膜移植术的结果存在差异，并且在伴有诸如晶状体切除术和玻璃体切除术等额外手术时失败几率更高，因此越来越多地为这些患者提供微创替代方案。值得注意的是最近报道的一种新手术：PA的选择性内皮切除术，该手术无需进行角膜移植，随着时间推移角膜混浊会逐渐消退。在本综述中，我们旨在描述PA的病因、分类、病理生理学、组织病理学、临床特征及治疗。
