Zhang Yinzhen, Wang Yanpeng, Xu Ji, Wang Zhengyan, Zhao Wenhai, Zhao Changwei
Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Department of Spinal Orthopedics, Weifang Hospital of Traditional Chinese Medicine, Weifang, China.
Front Med (Lausanne). 2024 Jan 5;10:1324449. doi: 10.3389/fmed.2023.1324449. eCollection 2023.
The relationship between visceral adipose tissue and osteoarthritis is not clear. The purpose of our study was to explore the relationship between visceral adipose tissue and osteoarthritis.
We used a two-sample Mendelian randomization method to select single-nucleotide polymorphisms (SNPs) significantly associated with visceral adipose tissue as instrumental variables to explore the relationship between visceral adipose tissue and all osteoarthritis, hand osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis. The reliability of the results was tested using sensitivity analysis.
Our findings indicated that visceral adipose tissue was associated with all osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis (all osteoarthritis: OR = 1.399, 95% CI: 1.335-1.467, = 7.95e-44; hip osteoarthritis: OR = 1.399, 95% CI: 1.284-1.524, = 1.41e-14; knee osteoarthritis: OR = 1.794, 95% CI: 1.662-1.937, = 1.33e-50; and spine osteoarthritis: OR = 1.445, 95% CI: 1.314-1.589, = 2.89e-14). Sensitivity analysis demonstrated the reliability of these results.
Our study suggests that genetically predicted visceral adipose tissue is associated with osteoarthritis. Reducing the accumulation of visceral adipose tissue could potentially have an impact on the incidence of osteoarthritis.
内脏脂肪组织与骨关节炎之间的关系尚不清楚。我们研究的目的是探讨内脏脂肪组织与骨关节炎之间的关系。
我们采用两样本孟德尔随机化方法，选择与内脏脂肪组织显著相关的单核苷酸多态性（SNP）作为工具变量，以探讨内脏脂肪组织与所有骨关节炎、手部骨关节炎、髋部骨关节炎、膝部骨关节炎和脊柱骨关节炎之间的关系。使用敏感性分析来检验结果的可靠性。
我们的研究结果表明，内脏脂肪组织与所有骨关节炎、髋部骨关节炎、膝部骨关节炎和脊柱骨关节炎相关（所有骨关节炎：比值比[OR]=1.399，95%置信区间[CI]：1.335-1.467，P=7.95×10⁻⁴⁴；髋部骨关节炎：OR=1.399，95%CI：1.284-1.524，P=1.41×10⁻¹⁴；膝部骨关节炎：OR=1.794，95%CI：1.662-1.937，P=1.33×10⁻⁵⁰；脊柱骨关节炎：OR=1.445，95%CI：1.314-1.589，P=2.89×10⁻¹⁴）。敏感性分析证明了这些结果的可靠性。
我们的研究表明，基因预测的内脏脂肪组织与骨关节炎相关。减少内脏脂肪组织的积累可能会对骨关节炎的发病率产生影响。
