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[一种复合疫苗在预防食管癌患者葡萄球菌、铜绿假单胞菌和变形杆菌感染中的应用]

[A complex vaccine in the prevention of staphylococcal, Pseudomonas aeruginosa and Proteus infections in esophageal cancer patients].

作者信息

Kochetkova V A, Moskovtseva R L, Mamontov A S

出版信息

Vopr Onkol. 1987;33(2):58-63.

PMID:3825005
Abstract

An analysis of clinico-immunological data has demonstrated a considerable decline in non-specific and specific defences against such major factors of hospital infection in esophageal cancer patients as staphylococcal, blue pus and Proteus bacilli. Immunization with a complex vaccine including concentrated staphylococcal anatoxin, blue pus and Proteus vaccines was shown to stimulate the said factors of anti-infectious immunity and to be followed by a 4.7-fold decrease in the incidence of postoperative pyo-inflammatory complications. The said vaccine may be recommended for prevention of infectious complications in cancer patients since its administration is followed by a low-level reaction matched by a marked increase in immunologic vigor.

摘要

对临床免疫学数据的分析表明,食管癌患者针对医院感染的主要因素(如葡萄球菌、绿脓杆菌和变形杆菌)的非特异性和特异性防御能力显著下降。使用包含浓缩葡萄球菌类毒素、绿脓杆菌和变形杆菌疫苗的复合疫苗进行免疫接种,可刺激上述抗感染免疫因素,并使术后脓性炎症并发症的发生率降低4.7倍。鉴于接种该疫苗后反应轻微,而免疫活力显著增强,因此可推荐使用该疫苗预防癌症患者的感染性并发症。

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