[Changes in the anti-infection immunity indices of esophageal cancer patients undergoing combined immunization against staphylococcal and Pseudomonas aeruginosa infections].

The method of the complex immunization of patients with esophageal cancer against the main causative agents of purulent infections has been developed. Purified concentrated staphylococcal toxoid and polyvalent corpuscular P. aeruginosa vaccine were used for the immunization of 26 patients. Immunization was carried out in 3 injections (11 patients) and 4 injections (15 patients) made at intervals of 7 days. This resulted in the activation of nonspecific immunity factors (the total bactericidal properties of the blood serum, the phagocytic activity of neutrophils, the increase of the IgG level) and in a considerable increase in the factors of specific protection against staphylococcal and P. aeruginosa infections: the titer of staphylococcal anti-alpha-toxin increased 7- to 11-fold and the titer of antibodies to P. aeruginosa antibodies increased 5- to 6.5-fold. The preoperative vaccination of patients decreased the occurrence of postoperative purulent complications from 71% to 11.5%.