Sharmanov T Sh, Eginchibaeva R G, Nikitin S A
Vopr Pitan. 1986 Nov-Dec(6):41-3.
The influence of immunization of lactating female rats with sheep red blood cells on the primary immune response of their progeny, and oral administration of heterologous antibodies, on the immune response of suckling rats was studied in experiments on 52 August rats. It was shown that oral antibody administration with breast milk and feeding with heterologous serum resulted in a drastic suppression of the splenic antibody-producing cells and in a fall of the humoral antibody titre in the suckling rats. The immunosuppression was reversible and could not be adoptively transferred. It is concluded that the antibodies entering the newborns' body with the mother's milk not only provide the passive immunity but also produce a regulatory effect on the immune system.
在对52只八月龄大鼠进行的实验中，研究了用绵羊红细胞对哺乳期雌性大鼠进行免疫接种对其子代初次免疫反应的影响，以及口服异源抗体对乳鼠免疫反应的影响。结果表明，通过母乳给予抗体和用异源血清喂养会导致乳鼠脾抗体产生细胞的急剧抑制和体液抗体滴度的下降。这种免疫抑制是可逆的，且不能过继转移。得出的结论是，随母乳进入新生儿体内的抗体不仅提供被动免疫，还对免疫系统产生调节作用。
