4-氨基苯丙酮导致高铁血红蛋白血症的性别差异。
Sex differences in the production of methaemoglobinaemia by 4-aminopropiophenone.
作者信息
Bright J E, Woodman A C, Marrs T C, Wood S G
出版信息
Xenobiotica. 1987 Jan;17(1):79-83. doi: 10.3109/00498258709047177.
PMID:3825178
Abstract
A methaemoglobin former, 4-aminopropiophenone (p-aminopropiophenone, PAPP), which is active only after metabolic activation in vivo, exhibits a sex difference in male Beagle dogs and bitches. Bitches produced more methaemoglobin for a given dose of PAPP than male dogs. The probable reason for this difference was a lower rate of N-hydroxylation in male dogs.
摘要
一种高铁血红蛋白形成剂，4-氨基苯丙酮（对氨基苯丙酮，PAPP），仅在体内经代谢活化后才具有活性，在雄性比格犬和雌性比格犬中表现出性别差异。对于给定剂量的PAPP，雌性犬产生的高铁血红蛋白比雄性犬更多。这种差异的可能原因是雄性犬的N-羟基化速率较低。
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