Yousefpour Parisa, Ni Kaiyuan, Irvine Darrell J
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Rev Bioeng. 2023 Feb;1(2):107-124. doi: 10.1038/s44222-022-00016-2. Epub 2023 Jan 30.
Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infectious diseases, cancer and autoimmunity. Biomaterials can promote specific targeting of immune cell subsets in peripheral or lymphoid tissues and modulate the dosage, timing and location of stimulation, thereby improving safety and efficacy of vaccines and immunotherapies. Here we review recent advances in biomaterials-based strategies, focusing on targeting of lymphoid tissues, circulating leukocytes, tissue-resident immune cells and immune cells at disease sites. These approaches can improve the potency and efficacy of immunotherapies by promoting immunity or tolerance against different diseases.
调节免疫系统的疗法为治疗包括传染病、癌症和自身免疫性疾病在内的多种病症带来了希望。生物材料可以促进对外周或淋巴组织中免疫细胞亚群的特异性靶向，并调节刺激的剂量、时间和位置，从而提高疫苗和免疫疗法的安全性和有效性。在此，我们综述基于生物材料策略的最新进展，重点关注淋巴组织、循环白细胞、组织驻留免疫细胞以及疾病部位免疫细胞的靶向。这些方法可以通过促进针对不同疾病的免疫或耐受性来提高免疫疗法的效力和疗效。
