犬体内 、基因与次级胆汁酸之间的相关性。 （你提供的原文中“Correlation between”后面缺少具体内容，以上是根据现有内容尽量准确翻译的结果 ）
Correlation between , the Gene, and Secondary Bile Acids in Dogs.
作者信息
Correa Lopes Bruna, Chen Chih-Chun, Sung Chi-Hsuan, Ishii Patricia Eri, Medina Luis Fernando da Costa, Gaschen Frederic P, Suchodolski Jan S, Pilla Rachel
机构信息
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX 77840, USA.
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
出版信息
Animals (Basel). 2024 Jan 9;14(2):216. doi: 10.3390/ani14020216.
Bile acid metabolism is a key pathway modulated by intestinal microbiota. () has been described as the main species responsible for the conversion of primary into secondary fecal unconjugated bile acids (fUBA) in dogs. This multi-step biochemical pathway is encoded by the bile acid-inducible () operon. We aimed to assess the correlation between abundance, the abundance of one specific gene of the operon (), and secondary fUBA concentrations. In this retrospective study, 133 fecal samples were analyzed from 24 dogs. The abundances of and were determined using qPCR. The concentration of fUBA was measured by gas chromatography-mass spectrometry. The abundance exhibited a strong positive correlation with secondary fUBA (ρ = 0.7377, 95% CI (0.6461, 0.8084), < 0.0001). Similarly, there was a strong correlation between and secondary fUBA (ρ = 0.6658, 95% CI (0.5555, 0.7532), 0.0001). Animals displaying conversion of fUBA and lacking were not observed. These results suggest is the main converter of primary to secondary bile acids in dogs.
胆汁酸代谢是由肠道微生物群调节的关键途径。（）已被描述为犬类中负责将初级粪便未结合胆汁酸（fUBA）转化为次级粪便未结合胆汁酸的主要菌种。这条多步骤生化途径由胆汁酸诱导型（）操纵子编码。我们旨在评估（）丰度、（）操纵子的一个特定基因（）的丰度与次级fUBA浓度之间的相关性。在这项回顾性研究中，分析了来自24只犬的133份粪便样本。使用qPCR测定（）和（）的丰度。通过气相色谱 - 质谱法测量fUBA的浓度。（）丰度与次级fUBA呈强正相关（ρ = 0.7377，95% CI（0.6461，0.8084），< 0.0001）。同样，（）与次级fUBA之间也存在强相关性（ρ = 0.6658，95% CI（0.5555，0.7532），< 0.0001）。未观察到显示fUBA转化且缺乏（）的动物。这些结果表明（）是犬类中初级胆汁酸向次级胆汁酸转化的主要转化菌。
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