Jankovic Velickovic Ljubinka, Ristic Petrovic Ana, Dolicanin Zana, Stojnev Slavica, Velickovic Filip, Basic Dragoslav
Center for Pathology, University Clinical Center Nis, 18000 Nis, Serbia.
Department of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
Biomedicines. 2024 Jan 1;12(1):95. doi: 10.3390/biomedicines12010095.
The aim of this study was to determine the association of basal compartment and superficial markers, comprising CK5/6, CD44, CK20, and the pathological characteristics of upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (BEN). Comparing the expression of the investigated markers in 54 tumors from the BEN region and 73 control UTUC, no significant difference between them was detected. In regression analysis, CK20 expression was not determined with expression of CK5/6, CD44, and the phenotypic characteristics of BEN and control UTUC. Parameters with predictive influence on the expression of CD44 in BEN UTUC included growth pattern ( = 0.010), necrosis ( = 0.019); differentiation ( = 0.001), and lymphovascular invasion ( = 0.021) in control UTUC. Divergent squamous differentiation in BEN tumors ( = 0.026) and stage in control tumors ( = 0.049) had a predictive influence on the expression of CK5/6. This investigation detected a predictive influence of the phenotypic characteristics of UTUC on the expression of basal compartment and superficial markers, with a significant influence of necrosis in BEN tumors ( = 0.006) and differentiation in control UTUC ( = 0.036).
本研究的目的是确定基底细胞层标志物和表面标志物（包括细胞角蛋白5/6（CK5/6）、CD44、细胞角蛋白20（CK20））与巴尔干地方性肾病（BEN）相关的上尿路尿路上皮癌（UTUC）病理特征之间的关联。比较BEN地区54例肿瘤和73例对照UTUC中所研究标志物的表达情况，未发现二者之间存在显著差异。在回归分析中，未确定CK20表达与CK5/6、CD44的表达以及BEN和对照UTUC的表型特征之间的关系。对BEN UTUC中CD44表达具有预测影响的参数包括生长模式（P = 0.010）、坏死（P = 0.019）；对对照UTUC中CD44表达具有预测影响的参数包括分化程度（P = 0.001）和淋巴管浸润（P = 0.021）。BEN肿瘤中的不同鳞状分化（P = 0.026）和对照肿瘤中的分期（P = 0.049）对CK5/6的表达具有预测影响。本研究发现UTUC的表型特征对基底细胞层标志物和表面标志物的表达具有预测影响，其中BEN肿瘤中的坏死（P = 0.006）和对照UTUC中的分化程度（P = 0.036）具有显著影响。
