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与急性 A 型主动脉夹层急诊手术患者术后新发神经并发症相关的因素。

Factors Associated with Newly Developed Postoperative Neurological Complications in Patients with Emergency Surgery for Acute Type A Aortic Dissection.

机构信息

Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania.

出版信息

Medicina (Kaunas). 2023 Dec 23;60(1):27. doi: 10.3390/medicina60010027.

Abstract

: Postoperative neurological complications (NCs) are an important cause of mortality in patients with acute type A aortic dissection (ATAAD). The aim of the study was to determine the association between intraoperative risk factors and newly developed postoperative NCs in patients after emergency surgery for ATAAD. : A total of 203 patients requiring emergency surgery were included in the study. Patients with preoperative neurological dysfunction, deceased on the operating table or within the first 48 h after intensive care admission, with uncertain postoperative neurologic status or with incomplete records were excluded. : Mean age was 57.61 ± 12.27 years. Hyperlipidemia was the most frequent comorbidity (69%). A bicuspid aortic valve was present in 12.8% of cases, severe acute aortic regurgitation was present in 29.1% of patients, and cardiac tamponade was present in 27.1% of cases. The innominate artery was the most frequently dissected supra-aortic artery in 27.1% of cases. In 65% of cases, the primary entry tear was at the level of the ascending aorta. The incidence of newly developed postoperative NCs was 39.4%. The most common surgical technique performed was supra-coronary ascending aorta and hemiarch replacement, in 53.2% of patients. Using logistic regression, cardiopulmonary bypass time (OR = 1.01; 95% CI = 1.01-1.02; < 0.001), aortic cross-clamp time over 3 h (OR = 2.71, 95% CI = 1.43-5.14, = 0.002) and cerebral perfusion time (OR = 1.02; 95% CI = 1.002-1.03; = 0.027) were independently associated with newly developed postoperative NCs. : Based on the results of the study, all efforts should be made to reduce operative times. Using a simple surgical technique, like the supra-coronary ascending aorta and hemiarch technique, whenever possible, and using a simpler technique for cerebral perfusion like unilateral cerebral perfusion via the right axillary artery, could reduce operating times.

摘要

术后神经系统并发症(NCs)是急性 A 型主动脉夹层(ATAAD)患者死亡的一个重要原因。本研究旨在确定接受紧急手术治疗的 ATAAD 患者术中危险因素与新出现的术后 NCs 之间的关系。

共有 203 名需要紧急手术的患者纳入本研究。排除术前神经功能障碍、手术台上死亡或重症监护入院后 48 小时内死亡、术后神经状态不确定或记录不完整的患者。

患者的平均年龄为 57.61 ± 12.27 岁。最常见的合并症是高脂血症(69%)。主动脉瓣二瓣化畸形见于 12.8%的病例,严重急性主动脉瓣反流见于 29.1%的患者,心脏压塞见于 27.1%的病例。无名动脉是最常发生夹层的升主动脉以上的主动脉,占 27.1%。在 65%的病例中,原发撕裂位于升主动脉水平。新出现的术后 NCs 的发生率为 39.4%。最常见的手术技术是冠状动脉以上升主动脉和半弓置换,占 53.2%的患者。使用逻辑回归,体外循环时间(OR=1.01;95%CI=1.01-1.02; < 0.001)、主动脉阻断时间超过 3 小时(OR=2.71;95%CI=1.43-5.14; = 0.002)和脑灌注时间(OR=1.02;95%CI=1.002-1.03; = 0.027)与新出现的术后 NCs 独立相关。

基于研究结果,应尽一切努力减少手术时间。尽可能使用简单的手术技术,如冠状动脉以上升主动脉和半弓技术,以及使用单侧经右腋动脉脑灌注等更简单的脑灌注技术,可减少手术时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d527/10820683/25da69a4842e/medicina-60-00027-g001.jpg

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