Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Medicina (Kaunas). 2023 Dec 25;60(1):38. doi: 10.3390/medicina60010038.
: The risk of developing cardiovascular diseases (CVD) in patients suffering from rheumatoid arthritis (RA) is two times higher compared to the general population. The objective of this retrospective study was to determine which cardiovascular complications can appear in men vs. women with rheumatoid arthritis. Early diagnosis and initiation of therapeutic measures to reduce the progression rate of rheumatoid arthritis, while also maintaining an active lifestyle, are the most important problems in young patients. : We included a number of 200 patients, divided into two groups according to gender (124 women and 76 men) with rheumatoid arthritis, presenting various stages of disease concomitant with cardiovascular complications. We assessed traditional and non-traditional risk factors, as well as electrocardiographic and echocardiographic findings in both groups. : All patients presented an atherogenic coefficient over two, indicating a significant risk of atherogenesis. Men had elevated levels of total cholesterol compared with women (≥200 mg/dL; 77.6%-men vs. 25.8%-women, < 0.001). The participants presented cardiac arrhythmias, especially in the active stage of RA. Women had an increased risk of atrial fibrillation by 2.308 times compared to men ( = 0.020). One of the most important complications found in young women was pulmonary arterial hypertension ( = 0.007). : In daily clinical practice, the screening of RA is carried out in sufficiently. This disease is often undiagnosed, and the risk factors remain unassessed. As a result, RA patients continue to present an increased risk of developing CVD.
:患有类风湿关节炎(RA)的患者发生心血管疾病(CVD)的风险比普通人群高两倍。本回顾性研究的目的是确定男性和女性 RA 患者可能出现哪些心血管并发症。早期诊断和开始治疗措施以降低 RA 的进展速度,同时保持积极的生活方式,是年轻患者最重要的问题。
:我们纳入了 200 名患者,根据性别分为两组(124 名女性和 76 名男性),均患有伴有心血管并发症的不同阶段的 RA。我们评估了两组的传统和非传统危险因素,以及心电图和超声心动图检查结果。
:所有患者的致动脉粥样硬化系数均超过 2,表明动脉粥样硬化形成的风险显著增加。与女性相比,男性的总胆固醇水平升高(≥200mg/dL;77.6%-男性与 25.8%-女性, < 0.001)。参与者表现出心律失常,尤其是在 RA 的活动期。与男性相比,女性发生心房颤动的风险增加了 2.308 倍( = 0.020)。在年轻女性中发现的最重要的并发症之一是肺动脉高压( = 0.007)。
:在日常临床实践中,对 RA 的筛查做得还不够。这种疾病常常未被诊断,且危险因素未被评估。因此,RA 患者继续面临 CVD 风险增加的问题。