Pak K, Iwasaki T, Miyakawa M, Yoshida O
Urol Res. 1979 Jun 22;7(2):119-24. doi: 10.1007/BF00254692.
Twenty-one anti-cancer drugs have been tested for their ability to cause mutations in Salmonella typhimurium test strains in the Salmonella/microsome mutagenicity test. Nine of the 21 anticancer drugs showed this ability: cyclophosphmide, nitromin, thio-tepa, busulfan, 6-mercaptopurine, neocarzinostatin, daunomycin, adriamycin and estramustine phosphate. Seven of these 9 mutagenic drugs were injected continuously into the jugular veins of rats. Urine was collected through a cystostomy tube and tested for mutagenicity. The urine from rats treated with 6 of these 7 drugs was mutagenic. These were cyclophosphamide, nitromin, thio-tepa, neocarzinostatin, adriamycin and daunomycin.
在沙门氏菌/微粒体诱变性试验中，对21种抗癌药物进行了测试，以检测它们在鼠伤寒沙门氏菌试验菌株中引起突变的能力。这21种抗癌药物中有9种表现出这种能力：环磷酰胺、癌得命、塞替派、白消安、6-巯基嘌呤、新制癌菌素、柔红霉素、阿霉素和磷酸雌莫司汀。将这9种诱变药物中的7种连续注入大鼠颈静脉。通过膀胱造瘘管收集尿液并检测其诱变性。用这7种药物中的6种处理过的大鼠尿液具有诱变性。这些药物是环磷酰胺、癌得命、塞替派、新制癌菌素、阿霉素和柔红霉素。
