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新型抗菌噻唑与各种杂环结合的构效关系概述（2017 - 2023年）

An Overview of the Structure-Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017-2023).

作者信息

Ungureanu Daniel, Tiperciuc Brîndușa, Nastasă Cristina, Ionuț Ioana, Marc Gabriel, Oniga Ilioara, Oniga Ovidiu

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania.

"Prof. Dr. Ion Chiricuță" Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania.

出版信息

Pharmaceutics. 2024 Jan 9;16(1):89. doi: 10.3390/pharmaceutics16010089.

DOI:10.3390/pharmaceutics16010089
PMID:38258100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10820536/
Abstract

Antimicrobial resistance is an increasing problem for global public health. One of the strategies to combat this issue is the synthesis of novel antimicrobials through rational drug design based on extensive structure-activity relationship studies. The thiazole nucleus is a prominent feature in the structure of many authorized antimicrobials, being clubbed with different heterocycles. The purpose of this review is to study the structure-activity relationship in antimicrobial thiazoles clubbed with various heterocycles, as reported in the literature between 2017 and 2023, in order to offer an overview of the last years in terms of antimicrobial research and provide a helpful instrument for future research in the field.

摘要

抗菌耐药性是全球公共卫生领域日益严重的问题。应对这一问题的策略之一是通过基于广泛构效关系研究的合理药物设计来合成新型抗菌药物。噻唑核是许多已获批准的抗菌药物结构中的一个显著特征，它与不同的杂环结合。本综述的目的是研究2017年至2023年文献报道的与各种杂环结合的抗菌噻唑的构效关系，以便概述近年来抗菌研究的情况，并为该领域的未来研究提供有用的工具。

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