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一些新型吡唑并[5,1-]噻唑衍生物的合成、表征及生物评价作为潜在的抗菌和抗癌剂。

Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents.

机构信息

Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.

Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.

出版信息

Molecules. 2021 Sep 4;26(17):5383. doi: 10.3390/molecules26175383.

DOI:10.3390/molecules26175383
PMID:34500816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8434505/
Abstract

The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, H and C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.

摘要

噻唑和吡唑部分作为抗菌和抗癌药物的药理学活性在许多文献综述中都有详细描述。在这项研究中，我们进行了一种新型吡唑并[5,1-α]噻唑杂环的方便合成。合成的化合物通过红外光谱、氢谱和碳谱以及质谱进行了表征。对一些选定的例子进行了筛选和评估，以测试它们的抗菌和抗癌活性，结果显示出有希望的结果。这些产物可以作为未来设计新药物分子的先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/e2ec183d2022/molecules-26-05383-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/9840e0f6e1c2/molecules-26-05383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/77fb6723ada5/molecules-26-05383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/74346e3d3521/molecules-26-05383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/1e273bd3b945/molecules-26-05383-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/d32ecebc4cd4/molecules-26-05383-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/44b319b83beb/molecules-26-05383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/8bcafe62952f/molecules-26-05383-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/e9d588009909/molecules-26-05383-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/e2ec183d2022/molecules-26-05383-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/9840e0f6e1c2/molecules-26-05383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/77fb6723ada5/molecules-26-05383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/74346e3d3521/molecules-26-05383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/1e273bd3b945/molecules-26-05383-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/d32ecebc4cd4/molecules-26-05383-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/44b319b83beb/molecules-26-05383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/8bcafe62952f/molecules-26-05383-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/e9d588009909/molecules-26-05383-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27ff/8434505/e2ec183d2022/molecules-26-05383-sch005.jpg

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