Voss Susanne, Hesse Albrecht, Zimmermann Diana J, Sauerbruch Tilman, von Unruh Gerd E
Department of Urology (Division of Experimental Urology), University of Bonn, Bonn, Germany.
J Urol. 2006 May;175(5):1711-5. doi: 10.1016/S0022-5347(05)01001-3.
We assessed the importance of oxalate hyperabsorption for idiopathic calcium oxalate urolithiasis, oxalate absorption in healthy volunteers and recurrent calcium oxalate stone formers was compared.
The [(13)C2]oxalate absorption test, a standardized, radioactivity-free test, was performed. On 2 days 24-hour urine was collected and an identical standard diet containing 800 mg Ca daily was maintained. On the morning of day 2 a capsule containing 0.37 mmol sodium [(13)C2]oxalate was ingested. A total of 120 healthy volunteers (60 women and 60 men) and 120 patients (30 women and 90 men) with idiopathic CaOx urolithiasis (60% or greater CaOx) were tested.
Mean intestinal oxalate absorption in the volunteers was 8.0 +/- 4.4%, and in the patients was 10.2 +/- 5.2% (p <0.001). There was no significant difference in mean absorption values between men and women within both groups. A high overlap between the absorption values of volunteers and patients was found. Only in the patient group did absorption values greater than 20% occur. Oxalate absorption correlated with oxalate excretion in the patients, r = 0.529 (p <0.01) and in the volunteers, r = 0.307 (p <0.01).
In high oxalate absorbers dietary oxalate has a significant role in oxalate excretion and, therefore, increases the risk of calcium oxalate stone formation.
我们评估了草酸盐过度吸收在特发性草酸钙尿石症中的重要性，比较了健康志愿者和复发性草酸钙结石形成者的草酸盐吸收情况。
进行了[(13)C2]草酸盐吸收试验，这是一种标准化的、无放射性的试验。在两天内收集24小时尿液，并维持相同的标准饮食，每日含钙800毫克。在第2天上午，摄入一粒含有0.37毫摩尔[(13)C2]草酸钠的胶囊。共对120名健康志愿者（60名女性和60名男性）和120名特发性草酸钙尿石症患者（60%或更多为草酸钙结石）（30名女性和90名男性）进行了测试。
志愿者的平均肠道草酸盐吸收为8.0±4.4%，患者为10.2±5.2%（p<0.001）。两组内男性和女性的平均吸收值无显著差异。发现志愿者和患者的吸收值有很大重叠。仅在患者组中出现大于20%的吸收值。患者的草酸盐吸收与草酸盐排泄相关，r = 0.529（p<0.01），志愿者中r = 0.307（p<0.01）。
在高草酸盐吸收者中，饮食中的草酸盐在草酸盐排泄中起重要作用，因此增加了草酸钙结石形成的风险。
