揭示下一次大流行的路径,从门诊到重症监护病房,维生素D缺乏在新冠疫情中的影响。
Shedding light on the next pandemic path, from outpatient to ICU, the effect of vitamin D deficiency in the SARS-CoV-2 pandemic.
作者信息
Celikmen F, Tunaligil V, Keles E C, Celikmen D S M, Sarikaya S
机构信息
Department of Emergency Medicine, Yeditepe Medical School, Yeditepe University, Istanbul, Türkiye.
Presidency of Disaster Health and Emergency Medical Services, TR MoH Health Directorate of Istanbul, Istanbul, Türkiye.
出版信息
Front Nutr. 2024 Jan 8;10:1268267. doi: 10.3389/fnut.2023.1268267. eCollection 2023.
BACKGROUND
Vitamin D insufficiency is named "the pandemic of our era" by some experts. World Health Organization warns against a "deadlier outbreak" than the COVID-19 pandemic. Critical evidence is hereby for future pandemic prevention, with special emphasis on Vitamin D.
METHODS
A cross-sectional study was conducted with 172 unvaccinated adult participants, who presented to the emergency department. Blood measurements, radiological findings, and demographic features were evaluated in the four categories of "healthy adults, COVID-19 outpatients, hospitalized inpatients on the wards, and in the ICU."
RESULTS
Results were statistically significant in association with age, gender, weight, Vitamin D, glucose, urea, creatinine, leucocyte, aspartate transaminase, hemoglobin, C-reactive protein, troponin, platelet/thrombocyte, ferritin, D-dimer, triglycerate, glycated haemoglobin, lactate dehydrogenase measurements, and chest computed tomography features (each < 0.050).
CONCLUSION
This article presents evidence to support the importance of Vitamin D for global public health. Patients with adequate levels of Vitamin D, glucose, urea, creatinine, leucocyte, aspartate transaminase, hemoglobin, C-reactive protein, troponin, platelet/thrombocyte, ferritin, D-dimer, triglycerate, glycated haemoglobin, lactate dehydrogenase are less likely to be admitted to ICU versus being outpatients. Factors include gender, age, weight, comorbidities, and computed tomography findings. The ultimate goal is to globally minimize preventable burdens of disease and death.
背景
维生素D缺乏被一些专家称为“我们这个时代的流行病”。世界卫生组织警告会出现比新冠疫情“更致命的疫情爆发”。在此提供关键证据以供未来的疫情预防,特别强调维生素D。
方法
对172名未接种疫苗的成年急诊患者进行了一项横断面研究。对“健康成年人、新冠门诊患者、病房住院患者以及重症监护病房患者”这四类人群的血液检测结果、影像学检查结果和人口统计学特征进行了评估。
结果
在年龄、性别、体重、维生素D、葡萄糖、尿素、肌酐、白细胞、天冬氨酸转氨酶、血红蛋白、C反应蛋白、肌钙蛋白、血小板、铁蛋白、D - 二聚体、甘油三酯、糖化血红蛋白、乳酸脱氢酶测量值以及胸部计算机断层扫描特征方面,结果具有统计学意义(每项均<0.050)。
结论
本文提供了证据支持维生素D对全球公共卫生的重要性。维生素D、葡萄糖、尿素、肌酐、白细胞、天冬氨酸转氨酶、血红蛋白、C反应蛋白、肌钙蛋白、血小板、铁蛋白、D - 二聚体、甘油三酯、糖化血红蛋白、乳酸脱氢酶水平充足的患者与门诊患者相比,入住重症监护病房的可能性较小。影响因素包括性别、年龄、体重、合并症以及计算机断层扫描结果。最终目标是在全球范围内尽量减少可预防的疾病和死亡负担。