Sang Lingli, Ge Yue, Liu Fucun, Wei Kai, Shen Xingyu, Zhang Yuxin, Li Zheng, Lu Wencen, Gao Xia, Zhang Yan
Department of Public Health, Kangda College of Nanjing Medical University, Lianyungang 222000, China.
Department of Otolaryngology Head and Neck Surgery of Xuzhou Cancer Hospital, XuZhou 2210000, China.
Ecotoxicol Environ Saf. 2024 Feb;271:115998. doi: 10.1016/j.ecoenv.2024.115998. Epub 2024 Jan 22.
Per- and poly-fluoroalkyl substances (PFAS) are ubiquitous chemicals in the environment and our daily lives. Several epidemiological studies have revealed that PFAS exposure is linked to male sex hormone levels; however, the conclusions are inconsistent across studies. Consequently, we performed a meta-analysis to systematically evaluate the association between PFAS exposure and male sex hormones.
The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) standards were followed during the meta-analysis. PubMed, Wed of Science, Embase, Cochrane Library, and Ovid databases were used to identify suitable articles before June 2023. The 95% CI and β values were calculated to assess the association between male sex hormone levels and PFAS exposure. Heterogeneity among the included studies was tested using inconsistency statistics (I).
The literature search identified 12 published articles that met our search criteria, involving 7506 participants. Our results revealed that perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA) exposures were negatively correlated with testosterone (β = -0.05; 95% CI: -0.09, -0.02, P = 0.003) and (β = -0.04; 95% CI: -0.08, 0.00, P = 0.049), respectively.
Exposure to PFNA and PFOA is negatively correlated with changes in male testosterone levels. This correlation suggests that we need to pay attention in the future to whether they are potential risk factors for male reproductive health.
全氟和多氟烷基物质（PFAS）是环境和我们日常生活中普遍存在的化学物质。多项流行病学研究表明，PFAS暴露与男性性激素水平有关；然而，各研究的结论并不一致。因此，我们进行了一项荟萃分析，以系统评估PFAS暴露与男性性激素之间的关联。
荟萃分析遵循系统评价和荟萃分析的首选报告项目（PRISMA）标准。在2023年6月之前，使用PubMed、科学网、Embase、Cochrane图书馆和Ovid数据库来识别合适的文章。计算95%置信区间（CI）和β值，以评估男性性激素水平与PFAS暴露之间的关联。使用不一致性统计量（I）检验纳入研究之间的异质性。
文献检索确定了12篇符合我们检索标准的已发表文章，涉及7506名参与者。我们的结果显示，全氟壬酸（PFNA）和全氟辛酸（PFOA）暴露分别与睾酮呈负相关（β = -0.05；95% CI：-0.09，-0.02，P = 0.003）和（β = -0.04；95% CI：-0.08，0.00，P = 0.049）。
PFNA和PFOA暴露与男性睾酮水平的变化呈负相关。这种相关性表明，我们未来需要关注它们是否是男性生殖健康的潜在风险因素。
