Department of Laboratory Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway; Department of Clinical Medicine, Endocrinological and Geriatric Research Group, UiT - The Arctic University of Norway, Hansine Hansens veg 18, 9019, Tromsø, Norway.
Department of Laboratory Medicine, University Hospital of North Norway, Hansine Hansens veg 67, 9019, Tromsø, Norway.
Environ Res. 2024 Feb 1;242:117703. doi: 10.1016/j.envres.2023.117703. Epub 2023 Nov 19.
Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents.
Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones were measured in 921 adolescents aged 15-19 years in the Fit Futures study, Northern Norway. The questionnaire included data on self-reported age at menarche and puberty development score (PDS). Multiple linear and logistic regression analyses and principle component analyses (PCA) were used to assess associations of PFAS with hormones concentrations and puberty indices.
In girls, total PFAS (∑PFAS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) were positively associated with dehydroepiandrosterone sulfate (DHEAS) and negatively associated with 11-deoxycorticosterone (11-DOC)/DHEAS ratio. In boys, the associations with 11-DOC/DHEAS ratio were positive for ∑PFAS, perfluoroheptanoate (PFHpA), perfluoroheptane sulfonate (PFHpS), PFOA, and PFOS. Perfluoroundecanoate (PFUnDA) was negatively associated with free thyroxine (fT4) and free triiodothyronine (fT3) in boys. PFNA and PFDA were also negatively associated with fT3 in boys. Serum parathyroid hormone concentration (PTH) was negatively associated with ∑PFAS and perfluorohexane sulfonate (PFHxS) in girls, and with PFOS in boys. PFDA and PFUnDA were positively associated with early menarche, while ∑PFAS and PFOA were positively associated with PDS in boys. No associations of PFAS with serum testosterone, follicle-stimulating hormone, or luteinizing hormone were found in either sex. In girls, PFOA was positively associated with free testosterone index (FTI). In boys, PFOA was positively associated with androstendione and 17-OH-progesterone, while PFHpA was positively associated with estradiol.
Serum concentrations of several PFAS were associated with parathyroid and steroid hormones in both sexes, and with thyroid hormones in boys, as well as with early menarche in girls and higher PDS in boys.
全氟和多氟烷基物质（PFAS）是一大类化学物质，在环境中无处不在，包括公认的持久性有机污染物。本横断面研究旨在探讨不同 PFAS 对青少年可能产生的内分泌干扰作用。
在挪威北部的 Fit Futures 研究中，对 921 名年龄在 15-19 岁的青少年测量了血清中 PFAS、甲状腺、甲状旁腺和类固醇激素的浓度。调查问卷包括关于自述初潮年龄和青春期发育评分（PDS）的数据。多元线性和逻辑回归分析以及主成分分析（PCA）用于评估 PFAS 与激素浓度和青春期指数的关联。
在女孩中，全氟烷基物质总量（∑PFAS）、全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）、全氟癸酸（PFDA）与硫酸脱氢表雄酮（DHEAS）呈正相关，与 11-脱氧皮质酮（11-DOC）/DHEAS 比值呈负相关。在男孩中，∑PFAS、全氟庚酸（PFHpA）、全氟庚烷磺酸（PFHpS）、PFOA 和 PFOS 与 11-DOC/DHEAS 比值呈正相关。在男孩中，全氟十一烷酸（PFUnDA）与游离甲状腺素（fT4）和游离三碘甲状腺原氨酸（fT3）呈负相关。在男孩中，PFNA 和 PFDA 也与 fT3 呈负相关。在女孩中，血清甲状旁腺激素浓度（PTH）与∑PFAS 和全氟己烷磺酸（PFHxS）呈负相关，与男孩中 PFOS 呈负相关。在男孩中，PFDA 和 PFUnDA 与初潮提前有关，而∑PFAS 和 PFOA 与男孩的 PDS 呈正相关。在男女两性中均未发现 PFAS 与血清睾酮、卵泡刺激素或黄体生成素有关。在女孩中，PFOA 与游离睾酮指数（FTI）呈正相关。在男孩中，PFOA 与雄烯二酮和 17-羟孕酮呈正相关，而 PFHpA 与雌二醇呈正相关。
在男女两性中，几种 PFAS 的血清浓度与甲状旁腺和类固醇激素有关，在男孩中与甲状腺激素有关，在女孩中与初潮提前有关，在男孩中与 PDS 较高有关。
