Clinical Research Centre, Sarawak General Hospital, Ministry of Health Malaysia, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia.
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Malaysia.
Sci Rep. 2024 Jan 23;14(1):1997. doi: 10.1038/s41598-024-52421-9.
Gastrointestinal (GI) cancers account for a significant incidence and mortality rates of cancers globally. Utilization of a phenomic data approach allows researchers to reveal the mechanisms and molecular pathogenesis of these conditions. We aimed to investigate the association between the phenomic features and GI cancers in a large cohort study. We included 502,369 subjects aged 37-73 years in the UK Biobank recruited since 2006, followed until the date of the first cancer diagnosis, date of death, or the end of follow-up on December 31st, 2016, whichever occurred first. Socio-demographic factors, blood chemistry, anthropometric measurements and lifestyle factors of participants collected at baseline assessment were analysed. Unvariable and multivariable logistic regression were conducted to determine the significant risk factors for the outcomes of interest, based on the odds ratio (OR) and 95% confidence intervals (CI). The analysis included a total of 441,141 participants, of which 7952 (1.8%) were incident GI cancer cases and 433,189 were healthy controls. A marker, cystatin C was associated with total and each gastrointestinal cancer (adjusted OR 2.43; 95% CI 2.23-2.64). In this cohort, compared to Asians, the Whites appeared to have a higher risk of developing gastrointestinal cancers. Several other factors were associated with distinct GI cancers. Cystatin C and race appear to be important features in GI cancers, suggesting some overlap in the molecular pathogenesis of GI cancers. Given the small proportion of Asians within the UK Biobank, the association between race and GI cancers requires further confirmation.
胃肠道（GI）癌症在全球范围内的发病率和死亡率都很高。利用表型数据方法可以帮助研究人员揭示这些疾病的机制和分子发病机制。我们旨在通过一项大型队列研究来研究表型特征与胃肠道癌症之间的关系。我们纳入了自 2006 年开始招募的英国生物库中 502369 名年龄在 37-73 岁之间的受试者，随访至首次癌症诊断、死亡日期或 2016 年 12 月 31 日随访结束的日期，以先发生者为准。分析了基线评估时收集的受试者的社会人口统计学因素、血液化学、人体测量和生活方式因素。基于比值比（OR）和 95%置信区间（CI），采用单变量和多变量逻辑回归来确定感兴趣结局的显著危险因素。该分析共纳入 441141 名参与者，其中 7952 名（1.8%）为新发胃肠道癌症病例，433189 名为健康对照。一种标志物，半胱氨酸蛋白酶抑制剂 C 与所有胃肠道癌症相关（调整后的 OR 2.43；95%CI 2.23-2.64）。在本队列中，与亚洲人相比，白人似乎患胃肠道癌症的风险更高。其他一些因素与不同的胃肠道癌症相关。半胱氨酸蛋白酶抑制剂 C 和种族似乎是胃肠道癌症的重要特征，提示胃肠道癌症的分子发病机制存在一些重叠。由于英国生物库中亚洲人的比例较小，种族与胃肠道癌症之间的关联需要进一步确认。
