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Supramolecular host-guest nanosystems for overcoming cancer drug resistance.

作者信息

Wu Sha, Yan Miaomiao, Liang Minghao, Yang Wenzhi, Chen Jingyu, Zhou Jiong

机构信息

Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, Liaoning, China.

Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, Guangdong, China.

出版信息

Cancer Drug Resist. 2023 Nov 22;6(4):805-827. doi: 10.20517/cdr.2023.77. eCollection 2023.

DOI:10.20517/cdr.2023.77
PMID:38263983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10804391/
Abstract

Cancer drug resistance has become one of the main challenges for the failure of chemotherapy, greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients. The emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld, providing a potential solution to this challenge. Compared with conventional chemotherapeutic platforms, supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake, reducing drug efflux, activating drugs, and inhibiting DNA repair. Herein, we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this field. It is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/c3125cc7086d/cdr-6-4-805.fig.13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/67bf0b1db6d4/cdr-6-4-805.scheme.1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/0162102432bd/cdr-6-4-805.fig.1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/72b4420d975e/cdr-6-4-805.fig.2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/846ce1e2f88b/cdr-6-4-805.fig.3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/f8f1f8e93bb8/cdr-6-4-805.fig.4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/902582f7c53d/cdr-6-4-805.fig.5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/ab9a46fb6357/cdr-6-4-805.fig.6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/b485e1fbc113/cdr-6-4-805.fig.7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/9d092379741c/cdr-6-4-805.fig.8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/4d5e80ad6eec/cdr-6-4-805.fig.9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/180e6ac43aed/cdr-6-4-805.fig.11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/8895a2d2ca3d/cdr-6-4-805.fig.12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/c3125cc7086d/cdr-6-4-805.fig.13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/67bf0b1db6d4/cdr-6-4-805.scheme.1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/0162102432bd/cdr-6-4-805.fig.1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/72b4420d975e/cdr-6-4-805.fig.2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/846ce1e2f88b/cdr-6-4-805.fig.3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/f8f1f8e93bb8/cdr-6-4-805.fig.4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/902582f7c53d/cdr-6-4-805.fig.5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/ab9a46fb6357/cdr-6-4-805.fig.6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/b485e1fbc113/cdr-6-4-805.fig.7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/9d092379741c/cdr-6-4-805.fig.8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/4d5e80ad6eec/cdr-6-4-805.fig.9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/180e6ac43aed/cdr-6-4-805.fig.11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/8895a2d2ca3d/cdr-6-4-805.fig.12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cd6/10804391/c3125cc7086d/cdr-6-4-805.fig.13.jpg

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[8]
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引用本文的文献

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Mol Cancer. 2024-9-13

[2]
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[3]
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本文引用的文献

[1]
Mitochondria in colorectal cancer stem cells - a target in drug resistance.

Cancer Drug Resist. 2023-5-6

[2]
Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system.

Cancer Drug Resist. 2023-6-20

[3]
Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects.

Cancer Drug Resist. 2023-4-29

[4]
Nanozyme for tumor therapy: Surface modification matters.

Exploration (Beijing). 2021-9-1

[5]
Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer.

Exploration (Beijing). 2021-8-27

[6]
Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry.

Molecules. 2023-5-29

[7]
Supramolecular Chemotherapy with Cucurbit[]urils as Encapsulating Hosts.

ACS Appl Bio Mater. 2023-6-19

[8]
Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy.

Chem Commun (Camb). 2023-3-23

[9]
Enhanced delivery of quercetin and doxorubicin using β-cyclodextrin polymer to overcome P-glycoprotein mediated multidrug resistance.

Int J Pharm. 2023-3-25

[10]
Cucurbituril curiosities.

Nat Chem. 2023-3

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